What is the distance between Florence and Greenville?

Florence and Greenville are 163 miles (263 km) apart.

What are the departure and arrival stations when taking the bus from Florence to Greenville?

If you're headed to Greenville from Florence, chances are that your bus will depart from Florence Bus Station and arrive at Guadalajara Supermarket Bus Stop. These are the main departure and arrival locations on this route, but you can find others that could fit better into your travel plans.

Bus Florence to Greenville from $172 | Refundable Tickets

Previously seen trips

Next departures for Florence to Greenville on November 24
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
	Bus	11:59pm	Florence, SC	13h 21m	1:20pm	1116 Woodruff Rd	No tags
Greyhound + FlixBus	Bus	5:35am	Florence, SC	16h 35m	10:10pm	1116 Woodruff Rd	No tags
	Bus	11:59pm	Florence, SC	12h 51m	12:50pm	1116 Woodruff Rd	No tags
Greyhound + FlixBus	Bus	5:35am	Florence, SC	16h 35m	10:10pm	1116 Woodruff Rd	No tags
	Bus	11:59pm	Florence, SC	12h 51m	12:50pm	1116 Woodruff Rd	No tags

Compare 2 ways to go from Florence to Greenville

We recommend taking the bus

Among the sustainable travel choices, the bus stands out as the good way to reach Greenville. The journey takes about 5 hours 55 minutes and with fares starting at just $80, it presents an excellent value for a comfortable ride.

2bus per day

5h 55mAverage Duration

151 milesDistance

6kgCO₂ emissions

	Average Price	Average Duration	CO₂ emissions	Actions
Bus	Average Price$80 - $186	Average Duration5h 55m	CO₂ emissions 6kg CO₂e
Train	Average Price$130 - $424	Average Duration18h 30m	CO₂ emissions 23kg CO₂e

Where are the popular stops in Florence and Greenville?

Stops in Florence

A
Florence Bus Station
619 S Irby St, Florence, SC 29501, USA
Visit page
B
TA Travel Center - Florence
2301 W Lucas St, Florence, SC 29501, USA

Stops in Greenville

A
Guadalajara Supermarket Bus Stop
2803 White Horse Rd, Greenville, SC 29611
B
Greenville Bus Station
9 Hendrix DR, Greenville, SC 29607

Compare bus companies

FlixBus

3.5/511,432 reviews

Staff4.2

Timeliness3.9

Cleanliness4.1

Wifi2.7

Flixbus is a European bus operator that offers intercity and bus travel in over 38 countries. Known for their easy-to-spot lime green buses and for offering affordable transportation between cities in Europe and the Americas, Flixbus is a good option for those looking for an affordable, reliable bus company. In their buses, you'll find free WiFi, bathrooms, and power outlets. You can also pay extra to choose your seat and get extra legroom, or even buy a snack or drink onboard directly from the driver. You can reschedule your ticket for a small fee, which varies from $1 to $5, depending on how close you are to the departure date.

US bus companies: FlixBus, BlaBlaCar Bus, ALSA, Greyhound, Intercape, Trenitalia, Sindbad

Frequently asked questions about traveling from Florence, SC, US to Greenville, SC by bus

What is the distance between Florence and Greenville?
What are the departure and arrival stations when taking the bus from Florence to Greenville?

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found

11/22

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11/23

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Today

$172

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The cheapest trip from Florence, SC, US to Greenville, SC was searched and found on Nov 24, 2025 with a price of $172

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Florence, SC, US to Greenville, SC, as early as possible.