Previously seen trips
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
Greyhound + FlixBus | Bus | Florence, SC | 1116 Woodruff Rd | No tags | ||||
FlixBus + Greyhound | Bus | Florence, SC | 1116 Woodruff Rd | No tags | ||||
 | Bus | Florence, SC | 1116 Woodruff Rd | No tags | ||||
FlixBus + Greyhound | Bus | Florence, SC | 1116 Woodruff Rd | No tags | ||||
| Bus | Florence, SC | 1116 Woodruff Rd | No tags |
Compare 2 ways to go from Florence to Greenville
Among the sustainable travel choices, the Bus stands out as a good way to reach Greenville. The journey takes about 5 hours 25 minutes and with fares starting at just $111, it presents an excellent value for a comfortable ride.
Where are the popular stops in Florence and Greenville?
Stops in Florence
- A619 S Irby St, Florence, SC 29501, USA
- B
TA Travel Center - Florence
2301 W Lucas St, Florence, SC 29501, USA
Stops in Greenville
- A
Guadalajara Supermarket Bus Stop
2803 White Horse Rd, Greenville, SC 29611 - B
Greenville Bus Station
9 Hendrix DR, Greenville, SC 29607
Compare bus companies
Flixbus is a European bus operator that offers intercity and bus travel in over 38 countries. Known for their easy-to-spot lime green buses and for offering affordable transportation between cities in Europe and the Americas, Flixbus is a good option for those looking for an affordable, reliable bus company. In their buses, you'll find free WiFi, bathrooms, and power outlets. You can also pay extra to choose your seat and get extra legroom, or even buy a snack or drink onboard directly from the driver. You can reschedule your ticket for a small fee, which varies from $1 to $5, depending on how close you are to the departure date.
Frequently asked questions about traveling from Florence, SC, US to Greenville, SC by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from Florence to Greenville?
The cheapest bus tickets from Florence to Greenville start from $111. The average price for this route is around $168. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Florence to Greenville?
The average bus trip duration from Florence to Greenville is 5h 25m, covering a distance of 151 miles (244 km). The quickest bus can get you there in 5h 25m and is operated by FlixBus.
Which bus companies service the Florence to Greenville route?
Several major bus companies operate on this route with 1 buses available per day.
What is the earliest and latest departure time for the bus from Florence to Greenville?
The earliest bus departs from Florence to Greenville at 2:00pm. And the latest bus departs at 2:00pm.
What are the CO₂ emissions for the bus trip from Florence to Greenville?
A bus trip from Florence to Greenville generates an estimated 6.0821 kg of CO₂, making it a highly eco-friendly travel option and recommended mode of travel by Busbud.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Florence, SC, US to Greenville, SC was searched and found on Apr 24, 2026 with a price of $103To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Florence, SC, US to Greenville, SC, as early as possible.
You can expect to pay from $103 to $103 for a bus ticket from Florence, SC, US to Greenville, SC based on the last 2 days. You can expect to find the cheapest price for the trip at $103 which is on 2026-04-24.
What's the cheapest way to go from Florence, SC, US to Greenville, SC?
The Bus is the cheapest travel choice for this destination
