Next available departures

Next departures for Indianapolis to St. Louis on August 22
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended	Price and booking link
		7:55pm	Indianapolis Bus Station	4h 20m	11:15pm	Gateway Station	CheapestFastest

Next departures for Indianapolis to St. Louis on August 23
Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
4:50am	Indianapolis Bus Station	3h 55m	7:45am	Gateway Station	CheapestFastest
6:40am	Greyhound Amtrak Station	6h 21m	12:01pm	Gateway Station	No tags
11:05am	Indianapolis Bus Station	5h 5m	3:10pm	Gateway Station	No tags
6:40am	Greyhound Amtrak Station	6h 21m	12:01pm	Gateway Station	No tags
7:55pm	Indianapolis Bus Station	4h 20m	11:15pm	Gateway Station	No tags
10:25am	Greyhound Amtrak Station	12h 58m	10:23pm	Gateway Station	No tags
10:25am	Greyhound Amtrak Station	12h 58m	10:23pm	Gateway Station	No tags

Next departures for Indianapolis to St. Louis on August 24
Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
11:05am	Indianapolis Bus Station	5h 5m	3:10pm	Gateway Station	Cheapest
4:50am	Indianapolis Bus Station	3h 55m	7:45am	Gateway Station	Fastest
6:40am	Greyhound Amtrak Station	6h 21m	12:01pm	Gateway Station	No tags
7:55pm	Indianapolis Bus Station	4h 20m	11:15pm	Gateway Station	No tags
6:40am	Greyhound Amtrak Station	6h 21m	12:01pm	Gateway Station	No tags
10:25am	Greyhound Amtrak Station	12h 58m	10:23pm	Gateway Station	No tags
10:25am	Greyhound Amtrak Station	12h 58m	10:23pm	Gateway Station	No tags

Next departures for Indianapolis to St. Louis on August 25
Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
11:05am	Indianapolis Bus Station	5h 5m	3:10pm	Gateway Station	Cheapest
4:50am	Indianapolis Bus Station	3h 55m	7:45am	Gateway Station	Fastest
6:40am	Greyhound Amtrak Station	6h 21m	12:01pm	Gateway Station	No tags
7:55pm	Indianapolis Bus Station	4h 20m	11:15pm	Gateway Station	No tags
6:40am	Greyhound Amtrak Station	6h 21m	12:01pm	Gateway Station	No tags

Last refresh of the prices: Yesterday at 10:30 PM EDT.

Compare 2 ways to go from Indianapolis to St. Louis

We recommend taking the bus

Among the sustainable travel choices, the Bus stands out as a good way to reach St. Louis. The journey takes about 4 hours 20 minutes, and with fares starting at just HK$283, it presents an excellent value for a comfortable ride.

3bus per day

4h 20mAverage Duration

371 kmDistance

9kgCO₂ emissions

	Average Price	Average Duration	CO₂ emissions	Actions
Bus	Average PriceHK$283 - HK$1,103	Average Duration4h 20m	CO₂ emissions 9kg CO₂e
Train	Average PriceHK$551 - HK$1,300	Average Duration14h	CO₂ emissions 34kg CO₂e

Bus stations and stops in Indianapolis and St. Louis

Stops in Indianapolis

A
Greyhound Amtrak Station
350 S Illinois St, Indianapolis, IN 46225
Visit page

Stops in St. Louis

A
Gateway Station
430 S 15th St, St Louis, MO 63103
Visit page

Compare companies

Greyhound

3.5/588,079 reviews

Staff3.6

Timeliness3.0

Cleanliness3.4

Wi‑Fi2.5

Based on 88079 reviews, the company was rated 3.5 stars on Busbud. Travellers were especially satisfied with the ticket access and the temperature but often complained with the Wi‑Fi. Greyhound ticket prices on this trip start at HK$283

Greyhound Indianapolis St. Louis recent customer reviews

The bus had some problems. Air conditioning was malfunctioning, and none of the outlets worked. There was also considerable damage to the seats that should have been repaired. The counter clerk was very friendly and helpful, but the bus driver seemed to be in a very bad mood and possibly ill, loudly coughing up phlegm the entire trip, and he gave us no indication of how late the bus was going to arrive. I will not ride Greyhound again if I can possibly avoid it.

Tremain X.

September 25, 2019

The 3:15 bus never arrived so I was forced to wait 6 hours at the station for the next departure. This was very poorly communicated to passengers and no effort was made for any sort of reimbursement. I will absolutely never use Greyhound again.

Matthew N.

August 16, 2018

Amtrak

4.1/56,450 reviews

Staff4.7

Timeliness3.8

Cleanliness4.5

Wi‑Fi3.6

FlixBus

3.5/515,300 reviews

Staff4.1

Timeliness3.9

Cleanliness4.1

Wi‑Fi2.7

Burlington Trailways

4.2/520 reviews

Staff5.0

Timeliness5.0

Cleanliness5.0

Wi‑Fi5.0

US bus companies:FlixBus, Greyhound, Futura, Chihuahuenses, Tufesa, Elite, Adirondack Trailways

Frequently asked questions about travelling from Indianapolis to St. Louis by bus

Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.

How much is the bus ticket from Indianapolis to St. Louis?
The cheapest bus tickets from Indianapolis to St. Louis start from HK$283. The average price for this route is around HK$331. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Indianapolis to St. Louis?
The average bus travel time from Indianapolis to St. Louis is 4h 20m, covering a distance of 371 km. The quickest bus can get you there in 3h 55m and is operated by Greyhound.
Which bus companies service the Indianapolis to St. Louis route?
Several major bus companies operate on this route with 3 buses available per day, including services from Greyhound, Amtrak, FlixBus, Burlington Trailways.
What are the earliest and latest departure times for the bus from Indianapolis to St. Louis?
The earliest bus departs from Indianapolis to St. Louis at 4:50am. And the latest bus departs at 11:25pm.
What are the CO₂ emissions for the bus trip from Indianapolis to St. Louis?
A bus trip from Indianapolis to St. Louis generates an estimated 9.26495 kg of CO₂, making it a highly eco-friendly travel option and a mode of travel recommended by Busbud.
What is the best bus company from Indianapolis to St. Louis?
According to Busbud customers, the highest-rated bus company on this route is Burlington Trailways, with an average rating of 4.2 out of 5 stars based on 20 reviews.
Which bus company has the best Wi-Fi from Indianapolis to St. Louis?
Based on Busbud reviews, the bus company Burlington Trailways has the highest Wi-Fi rating with a score of 5.0.
Which bus company has the best on-time performance from Indianapolis to St. Louis?
According to Busbud traveller reviews, the most punctual bus company on this route is Burlington Trailways, with a punctuality rating of 5.0 out of 5 stars.
Which bus company has the cleanest buses from Indianapolis to St. Louis?
According to Busbud traveller reviews, the bus company with the cleanest buses on this route is Burlington Trailways, with a cleanliness rating of 5.0 out of 5 stars.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found

08-20

HK$314

08-21

HK$354

Today

HK$346

08-23

HK$354

08-24

HK$298

08-25

HK$258

08-26

HK$250

08-27

HK$250

The cheapest trip from Indianapolis to St. Louis was searched and found on Aug 26, 2026 with a price of HK$250

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Indianapolis to St. Louis, as early as possible.

You can expect to pay from HK$250 to HK$1,399 for a bus ticket from Indianapolis to St. Louis based on the last 2 days. You can expect to find the cheapest price for the trip at HK$250 which is on 2026-08-26.

Usually Amtrak will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.