Previously seen trips
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | La Crosse (U of WI) | Indianapolis | No tags | ||||
| Bus | 314 Jay St., La Crosse | Indianapolis | No tags |
Get from La Crosse to Indianapolis
The journey takes about 1 day, 5 hours 25 minutes, and with fares starting at just $262, it presents an excellent value for a comfortable ride.
Compare bus companies
Based on 765 reviews, the company was rated 3.9 stars on Busbud. Travellers were especially satisfied with the ticket access and the temperature but often complained with the WiFi. Jefferson Lines ticket prices on this trip start at $262
Frequently asked questions about travelling from La Crosse, WI to Indianapolis by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from La Crosse to Indianapolis?
The cheapest bus tickets from La Crosse to Indianapolis start from $262. The average price for this route is around $262. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from La Crosse to Indianapolis?
The average bus travel time from La Crosse to Indianapolis is 1d 5h, covering a distance of 617 km. The quickest bus can get you there in 1d 5h and is operated by Jefferson Lines.
Which bus companies service the La Crosse to Indianapolis route?
Several major bus companies operate on this route with 2 buses available per day.
What are the earliest and latest departure times for the bus from La Crosse to Indianapolis?
The earliest bus departs from La Crosse to Indianapolis at 1:10pm. And the latest bus departs at 1:25pm.
What are the CO₂ emissions for the bus trip from La Crosse to Indianapolis?
A bus trip from La Crosse to Indianapolis generates an estimated 15 kg of CO₂, making it a highly eco-friendly travel option and a mode of travel recommended by Busbud.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from La Crosse, WI to Indianapolis was searched and found on Jan 13, 2026 with a price of $255To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from La Crosse, WI to Indianapolis, as early as possible.
