Bus Tickets from La Serena to Mendoza

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TueMay 20
from US$48
WedMay 21
from US$56
ThuMay 22
from US$48
FriMay 23
from US$46
SatMay 24
from US$56
SunMay 25
MonMay 26
TueMay 27

Cheap buses leaving Wednesday

One passenger / one way

  • This trip is recommended because it is the: Cheapest
    Departure time: May 21 at
    Departure city: La Serena
    Departure location: Terminal de Buses La Serena
    Arrival time: May 22 at
    Destination city: Mendoza
    Destination location: Terminal De Omnibus Guaymallen
    Operated by: Buses Romani + CATA Internacional
    Buses Romani + CATA Internacional
    Vehicle: BusDuration:
  • This trip is recommended because it is the: Fastest
    Departure time: May 21 at
    Departure city: La Serena
    Departure location: Terminal de Buses La Serena
    Arrival time: May 22 at
    Destination city: Mendoza
    Destination location: Terminal De Omnibus Guaymallen
    Operated by: Pullman San Andrés + CATA Internacional
    Pullman San Andrés + CATA Internacional
    Vehicle: BusDuration:
  • Departure time: May 21 at
    Departure city: La Serena
    Departure location: Terminal de Buses La Serena
    Arrival time: May 22 at
    Destination city: Mendoza
    Destination location: Terminal De Omnibus Guaymallen
    Operated by: Pullman San Andrés + CATA Internacional
    Pullman San Andrés + CATA Internacional
    Vehicle: BusDuration:
  • Departure time: May 21 at
    Departure city: La Serena
    Departure location: Terminal de Buses La Serena
    Arrival time: May 22 at
    Destination city: Mendoza
    Destination location: Terminal De Omnibus Guaymallen
    Operated by: Buses Romani + CATA Internacional
    Buses Romani + CATA Internacional
    Vehicle: BusDuration:

Last refresh of the prices: Yesterday at 11:06 PM -04.

Prices and availability are subject to change.

Accepted payments

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Bus La Serena to Mendoza: Trip Overview

Average Ticket PriceUS$52
Average Bus Trip Duration17h
Number of daily buses4
Earliest bus departure2:00am
Distance404 km
Latest bus departure11:59pm

La Serena to Mendoza Bus

With Busbud, comparing and booking tickets for a bus from La Serena to Mendoza is a breeze. Browse through an extensive selection of bus fares and bus schedules to find the best deals.

We make it our job to connect you with the most dependable bus companies that cover bus service from La Serena to Mendoza.

Whether it is cheap bus tickets or more luxurious buses going to Mendoza from La Serena, we help you find what you're looking for based on how much of a budget you have.

Frequently asked questions on the trip La Serena - Mendoza

  1. How long is the trip from La Serena to Mendoza by bus?

    The trip from La Serena to Mendoza will take on average 17h. If you're looking for the fastest way to get there, you'll find a bus doing the trip in about 12h 15m.

  2. What is the travel distance from La Serena to Mendoza?

    It's about 405 km (251 miles) from La Serena to Mendoza.

  3. What are the departure and arrival locations for buses traveling from La Serena to Mendoza?

    Buses departing from Terminal de Buses La Serena in La Serena will take you to Mendoza Terminal in Mendoza.

  4. What is the cheapest way to travel from La Serena to Mendoza?

    If you're on a budget, consider traveling by bus to Mendoza from La Serena; it tends to be more affordable. With a starting ticket price of US$47, this bus becomes your top pick for this journey.

  5. How much does the bus ticket cost from La Serena to Mendoza?

    You can expect to pay around US$52 for the bus ride from La Serena to Mendoza.

  6. Is there an overnight bus from La Serena to Mendoza?

    Yes! If you're heading from La Serena to Mendoza, you'll find buses departing until 11:59pm and arriving the next day.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
05-16
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05-17
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Today
US$81
05-19
No data
05-20
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05-21
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05-22
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05-23
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busbud logoThe cheapest trip from La Serena to Mendoza was searched and found on May 18, 2025 with a price of US$81

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from La Serena to Mendoza, as early as possible.

About Bus Travel

Bus Travel Tips

Meet and talk to locals at the bus stations while travelling from La Serena to Mendoza.There is no better way to get inside travel information while exploring a new city than to go straight to its people.

From miles long of beauteous natural landscapes to impressive man-crafted sights, you’re bound to be in for a visual treat on your bus trip from La Serena to Mendoza.

Buses are energy-efficient. Carrying a passenger over 100 kms by coach only takes 0.6-0.9 liters of gas. Compare that to the 2.6 liters required by high-speed train, 6.6 liters by airplane and 7.6 liters by gas-powered car, and it's clear that the bus is a more environmentally-conscious option for your bus transportation from La Serena to Mendoza.

Make a music playlist for your bus ride from La Serena to Mendoza, and enjoy the scenery to tunes from your own personal soundtrack.

Did you know?

The Superbus, created by a Dutch engineer is the world's fastest bus with 250 km/h. Too bad it's only a prototype for now.

Did you know some bus companies in Germany offer to their passenger low-costs snacks and regional beer based on their destination? Prosit!

The word 'bus' is an abbreviation of 'omnibus" which means 'for all' in Latin as buses were meant to be transportation for everybody.

Will you be returning to La Serena by bus?

Bus from La Serena to Mendoza

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