Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
Cikbus Elité + Ahumada Internacional | Bus | Terminal de Buses La Serena | Terminal Mendoza. | Cheapest | ||||
 | Bus | Terminal de Buses La Serena | Mendoza Terminal | Fastest | ||||
| Bus | Terminal de Buses La Serena | Mendoza Terminal | No tags | ||||
Cikbus Elité + CATA Internacional | Bus | Terminal de Buses La Serena | Mendoza Terminal | No tags | ||||
Cikbus Elité + Andesmar | Bus | Terminal de Buses La Serena | Mendoza Terminal | No tags |
Last refresh of the prices: Today at 9:30 PM -03.
Get from La Serena to Mendoza
The journey takes about 17 hours and with fares starting at just $63, it presents an excellent value for a comfortable ride.
Where are the popular stops in La Serena and Mendoza?
Stops in La Serena
- AAmunátegui 107, La Serena, Región de Coquimbo, Chile
- B
Rotonda La Serena
Panamericana Norte 208, La Serena, Región de Coquimbo, Chile
Stops in Mendoza
- AAv. Gdor. Ricardo Videla, Mendoza, Argentina
- BAcceso A Aeropuerto Internacional Gabrielli F. J., Las Heras, Mendoza, Argentina
- CChile 1124, 5500 Mendoza, Argentina
- D
Parada de Autobuses de Mendoza - Vallecitos
Huarpes 3124, Las Heras, Mendoza, Argentina - E
Parada de Autobuses de Mendoza - Nogoli
Nogoli 699, M5501HVC Godoy Cruz, Mendoza, Argentina - F
Vistalba 3020
Vistalba 3020, Godoy Cruz, Mendoza, Argentina
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Frequently asked questions about traveling from La Serena, CL to Mendoza, AR by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from La Serena to Mendoza?
The cheapest bus tickets from La Serena to Mendoza start from $63. The average price for this route is around $77. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from La Serena to Mendoza?
The average bus trip duration from La Serena to Mendoza is 17h, covering a distance of 251 miles (404 km). The quickest bus can get you there in 13h 15m and is operated by CATA Internacional.
Which bus companies service the La Serena to Mendoza route?
Several major bus companies operate on this route with 7 buses available per day, including services from CATA Internacional, Pluss Chile, Cikbus Elité, Buses Andimar, Pullman San Andres, Buses Romani, Serena Mar.
What is the earliest and latest departure time for the bus from La Serena to Mendoza?
The earliest bus departs from La Serena to Mendoza at 12:45am. And the latest bus departs at 11:59pm.
What are the CO₂ emissions for the bus trip from La Serena to Mendoza?
A bus trip from La Serena to Mendoza generates an estimated 10 kg of CO₂, making it a highly eco-friendly travel option and recommended mode of travel by Busbud.
What is the best bus company from La Serena to Mendoza?
According to Busbud customers, the highest-rated bus company on this route is Buses Andimar, with an average rating of 4.1 out of 5 stars based on 56 reviews.
Which bus company has the best Wi-Fi from La Serena to Mendoza?
Based on reviews on Busbud, the bus company CATA Internacional has the best Wi-Fi rating with a score of 1.7.
Which bus company has the most timely service from La Serena to Mendoza?
According to Busbud traveller reviews, the most timely bus company on this route is Buses Romani, with a punctuality rating of 4.5 out of 5 stars.
Which bus company has the cleanest buses from La Serena to Mendoza?
According to Busbud traveller reviews, the bus company with the cleanest buses on this route is Pluss Chile, with a cleanliness rating of 4.5 out of 5 stars.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from La Serena, CL to Mendoza, AR was searched and found on Jan 8, 2026 with a price of $97To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from La Serena, CL to Mendoza, AR, as early as possible.
You can expect to pay from $97 to $116 for a bus ticket from La Serena, CL to Mendoza, AR based on the last 2 days. You can expect to find the cheapest price for the trip at $97 which is on 2026-01-08.
