Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
Greyhound Lines, Inc. + Greyhound Lines Mexico | Bus | Mesa Bus Stop | San Antonio Bus Station | Cheapest | ||||
 | Bus | Mesa Bus Stop | San Antonio Bus Station | Fastest | ||||
Greyhound Lines, Inc. + Valley Transit | Bus | Mesa Bus Stop | San Antonio Bus Station | No tags |
Last refresh of the prices: Today at 8:21 AM MST.
Get from Mesa to San Antonio
The journey takes about 1 day, 3 hours 15 minutes, and with fares starting at just $258, it presents an excellent value for a comfortable ride.
Where are the popular stops in Mesa and San Antonio?
Stops in Mesa
- A
Mesa Bus Station
1423 S Country Club , Mesa, AZ 85210, USA
Stops in San Antonio
- A500 N St Mary's St, San Antonio, TX 78205, USA
- B7914 Interstate 35 Access Rd, San Antonio, TX 78224, USA
- C165 Bowie St, San Antonio, 78205
- D4407 S PanAm Expy #101, San Antonio, TX 78225, USA
Compare bus companies
Based on 87489 reviews, the company was rated 3.5 stars on Busbud. Travellers were especially satisfied with the ticket access and the temperature but often complained with the WiFi. Greyhound ticket prices on this trip start at $284
Frequently asked questions about travelling from Mesa to San Antonio, US by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from Mesa to San Antonio?
The cheapest bus tickets from Mesa to San Antonio start from $258. The average price for this route is around $339. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Mesa to San Antonio?
The average bus travel time from Mesa to San Antonio is 1d 3h, covering a distance of 1340 km. The quickest bus can get you there in 19h 35m and is operated by Greyhound.
Which bus companies service the Mesa to San Antonio route?
Several major bus companies operate on this route with 2 buses available per day.
What are the earliest and latest departure times for the bus from Mesa to San Antonio?
The earliest bus departs from Mesa to San Antonio at 3:50am. And the latest bus departs at 7:15pm.
What are the CO₂ emissions for the bus trip from Mesa to San Antonio?
A bus trip from Mesa to San Antonio generates an estimated 33 kg of CO₂, making it a highly eco-friendly travel option and a mode of travel recommended by Busbud.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Mesa to San Antonio, US was searched and found on Jan 12, 2026 with a price of $149To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Mesa to San Antonio, US, as early as possible.
You can expect to pay from $149 to $265 for a bus ticket from Mesa to San Antonio, US based on the last 2 days. You can expect to find the cheapest price for the trip at $149 which is on 2026-01-12.
