Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Exit 122 Park & Ride | Syracuse University | CheapestFastest | ||||
| Bus | Exit 122 Park & Ride | Amtrak Station | No tags |
Last refresh of the prices: Last Sunday at 4:29 PM EST.
Get from Middletown to Syracuse
The journey takes about 3 hours 40 minutes, and with fares starting at just $98, it presents an excellent value for a comfortable ride.
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Where are the popular stops in Middletown and Syracuse?
Frequently asked questions about travelling from Middletown, NY, US to Syracuse, US by bus
What is the travel distance from Middletown to Syracuse?
The distance between Middletown and Syracuse is approximately 227 km (141 miles).
What are the departure and arrival locations for buses traveling from Middletown to Syracuse?
Buses departing from Exit 122 Park & Ride in Middletown will take you to Regional Transportation Center in Syracuse.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Middletown, NY, US to Syracuse, US was searched and found on Nov 21, 2025 with a price of $100To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Middletown, NY, US to Syracuse, US, as early as possible.
You can expect to pay from $100 to $107 for a bus ticket from Middletown, NY, US to Syracuse, US based on the last 2 days. You can expect to find the cheapest price for the trip at $100 which is on 2025-11-21.
