What is the travel distance from Middletown to Syracuse?

Middletown and Syracuse are 141 miles (227 km) apart.

What are the departure and arrival stations when taking the bus from Middletown to Syracuse?

The majority of buses traveling from Middletown to Syracuse start their journey at Exit 122 Park & Ride and wind up at Regional Transportation Center. These are the most popular departure and arrival locations on this route, there are other pick-up and drop-off locations that could make it easier for you to reach your destination.

What are the best sights and things to do in Syracuse?

Once in Syracuse, you can start exploring the city and discover its surroundings. The top sights and things to do are Erie Canal Museum, The Fun Warehouse, Landmark Theatre, Regal Destiny USA Stadium 19 IMAX & RPX and Webster Pond.

Bus Middletown to Syracuse from $60 | Refundable Tickets

Next bus departures

Next departures for Middletown to Syracuse on November 21
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended	Price and booking link
	Bus	3:15pm	Exit 122 Park & Ride	3h 25m	6:40pm	Syracuse University	CheapestFastest
	Bus	3:15pm	Exit 122 Park & Ride	3h 40m	6:55pm	Amtrak Station	No tags

Last refresh of the prices: Last Sunday at 4:29 PM EST.

Get from Middletown to Syracuse

This route is served by bus only

The journey takes about 3 hours 40 minutes and with fares starting at just $68, it presents an excellent value for a comfortable ride.

2bus per day

3h 40mAverage Duration

146 milesDistance

6kgCO₂ emissions

Compare bus companies

Adirondack Trailways

4/51,125 reviews

Staff4.6

Timeliness4.3

Cleanliness4.8

Wifi2.4

OurBus

4/53,148 reviews

Staff4.4

Timeliness4.1

Cleanliness4.3

Wifi3.1

With about 1 daily trips between Middletown and Syracuse, Ourbus offers competitive fares, clean and comfortable intercity bus travel. Their buses have free WiFi, clean bathrooms, complimentary bottled water, extra legroom and power outlets. They are known for providing excellent customer service, reflecting one of the industry's highest review rates. OurBus does not charge fees to reschedule tickets, which can be changed up to 30 minutes before travel time.

US bus companies: FlixBus, BlaBlaCar Bus, ALSA, Greyhound, Intercape, Trenitalia, Sindbad

Where are the popular stops in Middletown and Syracuse?

Stops in Middletown

A - Exit 122 Park & Ride

Stops in Syracuse

A - Regional Transportation Center

B - Syracuse University

C - Syracuse Airport

D - Syracuse University - Lyman Hall

E - New York State Fairgrounds

F - Syracuse, NY

Frequently asked questions about traveling from Middletown, NY, US to Syracuse, US by bus

What is the travel distance from Middletown to Syracuse?
What are the departure and arrival stations when taking the bus from Middletown to Syracuse?
What are the best sights and things to do in Syracuse?

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found

11/16

$81

11/17

$72

Today

No data

11/19

No data

11/20

No data

11/21

$69

11/22

No data

11/23

No data

The cheapest trip from Middletown, NY, US to Syracuse, US was searched and found on Nov 21, 2025 with a price of $69

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Middletown, NY, US to Syracuse, US, as early as possible.

You can expect to pay from $69 to $84 for a bus ticket from Middletown, NY, US to Syracuse, US based on the last 2 days. You can expect to find the cheapest price for the trip at $69 which is on 2025-11-21.