Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Orlando Bus Station | Lake City Bus Station | CheapestFastest | ||||
FlixBus + Greyhound Lines, Inc. | Bus | Orlando Bus Station | Lake City Bus Station | No tags |
Last refresh of the prices: Yesterday at 4:16 AM EST.
Get from Orlando to Lake City
The journey takes about 3 hours 45 minutes, and with fares starting at just $49, it presents an excellent value for a comfortable ride.
Where are the popular stops in Orlando and Lake City?
Stops in Orlando
- A555 N John Young Pkwy, Orlando, FL 32805
- BRedCoach Station, 1777 McCoy Road, Orlando, FL 32809
- CJet Set Express Terminal, 3718 LB Mcleod Rd., 32805 Orlando, FL,, United States
- D
Disney World
Disney's All-Star Sports Resort, 1701 West Buena Vista Dr., Orlando, FL 32830 - E
International Dr SuperTours Terminal
5419 International Dr, Orlando, FL 32819, USA - F
Seaworld Hotels
10100 International Drive , Orlando, 32821
Stops in Lake City
- A2470 W US HWY 90, Lake City, FL 32025, USA
- B
Lake City Greyhound Bus Station
251 S MARION AVE , 32055, Florida
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Frequently asked questions about travelling from Orlando to Lake City by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from Orlando to Lake City?
The cheapest bus tickets from Orlando to Lake City start from $49. The average price for this route is around $64. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Orlando to Lake City?
The average bus travel time from Orlando to Lake City is 3h 45m, covering a distance of 218 km. The quickest bus can get you there in 3h 20m and is operated by FlixBus.
Which bus companies service the Orlando to Lake City route?
What are the earliest and latest departure times for the bus from Orlando to Lake City?
The earliest bus departs from Orlando to Lake City at 5:15am. And the latest bus departs at 12:30pm.
What are the CO₂ emissions for the bus trip from Orlando to Lake City?
A bus trip from Orlando to Lake City generates an estimated 5 kg of CO₂, making it a highly eco-friendly travel option and a mode of travel recommended by Busbud.
What is the best bus company from Orlando to Lake City?
According to Busbud customers, the highest-rated bus company on this route is FlixBus, with an average rating of 3.5 out of 5 stars based on 11380 reviews.
Which bus company has the best Wi-Fi from Orlando to Lake City?
Based on Busbud reviews, the bus company FlixBus has the highest Wi-Fi rating with a score of 2.7.
Which bus company has the best on-time performance from Orlando to Lake City?
According to Busbud traveller reviews, the most punctual bus company on this route is FlixBus, with a punctuality rating of 3.9 out of 5 stars.
Which bus company has the cleanest buses from Orlando to Lake City?
According to Busbud traveller reviews, the bus company with the cleanest buses on this route is FlixBus, with a cleanliness rating of 4.1 out of 5 stars.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Orlando to Lake City was searched and found on Nov 28, 2025 with a price of $59To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Orlando to Lake City, as early as possible.
You can expect to pay from $59 to $72 for a bus ticket from Orlando to Lake City based on the last 2 days. You can expect to find the cheapest price for the trip at $59 which is on 2025-11-30.
Usually Greyhound will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.
