How much is the bus ticket from Pittsburgh to San Diego?

The cheapest bus tickets from Pittsburgh to San Diego start from $371. The average price for this route is around $508. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.

How long is the bus ride from Pittsburgh to San Diego?

The average bus travel time from Pittsburgh to San Diego is 2d 15h, covering a distance of 3403 km. The quickest bus can get you there in 2d 9h and is operated by Greyhound .

Which bus companies service the Pittsburgh to San Diego route?

Several major bus companies operate on this route with 10 buses available per day.

What are the earliest and latest departure times for the bus from Pittsburgh to San Diego?

The earliest bus departs from Pittsburgh to San Diego at 1:35am. And the latest bus departs at 8:00pm.

What are the CO₂ emissions for the bus trip from Pittsburgh to San Diego?

A bus trip from Pittsburgh to San Diego generates an estimated 85 kg of CO₂, making it a highly eco-friendly travel option and a mode of travel recommended by Busbud.

Bus Pittsburgh to San Diego from $464 | Refundable Tickets

Next bus departures

Next departures for Pittsburgh to San Diego on December 13
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
Greyhound Lines, Inc. + FlixBus	Bus	8:00pm	Pittsburgh Intermodal Station	3d 5h	10:15pm	Downtown SD (Seaport)	Cheapest
Greyhound Lines, Inc. + FlixBus	Bus	10:50am	Pittsburgh Intermodal Station	2d 9h	5:35pm	UCSD Health La Jolla Station	Fastest
Greyhound Lines, Inc. + FlixBus	Bus	10:50am	Pittsburgh Intermodal Station	2d 10h	6:10pm	San Diego (Old Town-FlixBus)	No tags
	Bus	10:50am	Pittsburgh Intermodal Station	2d 9h	5:45pm	Greyhound Bus Stop	No tags
Greyhound Lines, Inc. + FlixBus	Bus	10:50am	Pittsburgh Intermodal Station	2d 14h	10:15pm	Downtown SD (Seaport)	No tags

Next departures for Pittsburgh to San Diego on December 14
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
Greyhound Lines, Inc. + FlixBus	Bus	8:00pm	Pittsburgh Intermodal Station	3d 5h	10:15pm	Downtown SD (Seaport)	Cheapest
Greyhound Lines, Inc. + FlixBus	Bus	10:50am	Pittsburgh Intermodal Station	2d 9h	5:35pm	UCSD Health La Jolla Station	Fastest
Greyhound Lines, Inc. + FlixBus	Bus	10:50am	Pittsburgh Intermodal Station	2d 10h	6:10pm	San Diego (Old Town-FlixBus)	No tags
	Bus	10:50am	Pittsburgh Intermodal Station	2d 9h	5:45pm	Greyhound Bus Stop	No tags
Greyhound Lines, Inc. + FlixBus	Bus	10:50am	Pittsburgh Intermodal Station	2d 14h	10:15pm	Downtown SD (Seaport)	No tags

Next departures for Pittsburgh to San Diego on December 15
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
Greyhound Lines, Inc. + FlixBus	Bus	8:00pm	Pittsburgh Intermodal Station	2d 20h	1:40pm	UCSD Health La Jolla Station	Cheapest
Greyhound Lines, Inc. + FlixBus	Bus	10:50am	Pittsburgh Intermodal Station	2d 9h	5:35pm	UCSD Health La Jolla Station	Fastest
Greyhound Lines, Inc. + FlixBus	Bus	10:50am	Pittsburgh Intermodal Station	2d 10h	6:10pm	San Diego (Old Town-FlixBus)	No tags
	Bus	10:50am	Pittsburgh Intermodal Station	2d 16h	11:50pm	Greyhound Bus Stop	No tags
Greyhound Lines, Inc. + FlixBus	Bus	8:00pm	Pittsburgh Intermodal Station	2d 21h	2:10pm	San Diego (Old Town-FlixBus)	No tags

Next departures for Pittsburgh to San Diego on December 16
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
Greyhound Lines, Inc. + FlixBus	Bus	1:35am	Pittsburgh Intermodal Station	2d 15h	1:40pm	UCSD Health La Jolla Station	Cheapest
Greyhound Lines, Inc. + FlixBus	Bus	10:50am	Pittsburgh Intermodal Station	2d 9h	5:35pm	UCSD Health La Jolla Station	Fastest
Greyhound Lines, Inc. + FlixBus	Bus	1:35am	Pittsburgh Intermodal Station	2d 15h	2:10pm	San Diego (Old Town-FlixBus)	No tags
	Bus	10:50am	Pittsburgh Intermodal Station	2d 16h	11:50pm	Greyhound Bus Stop	No tags
Greyhound Lines, Inc. + FlixBus	Bus	10:50am	Pittsburgh Intermodal Station	2d 10h	6:10pm	San Diego (Old Town-FlixBus)	No tags

Next departures for Pittsburgh to San Diego on December 17
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
Greyhound Lines, Inc. + FlixBus	Bus	8:00pm	Pittsburgh Intermodal Station	2d 20h	1:40pm	UCSD Health La Jolla Station	Cheapest
Greyhound Lines, Inc. + FlixBus	Bus	10:50am	Pittsburgh Intermodal Station	2d 9h	5:35pm	UCSD Health La Jolla Station	Fastest
Greyhound Lines, Inc. + FlixBus	Bus	1:35am	Pittsburgh Intermodal Station	2d 15h	2:10pm	San Diego (Old Town-FlixBus)	No tags
	Bus	10:50am	Pittsburgh Intermodal Station	2d 9h	5:45pm	Greyhound Bus Stop	No tags
Greyhound Lines, Inc. + FlixBus	Bus	10:50am	Pittsburgh Intermodal Station	2d 10h	6:10pm	San Diego (Old Town-FlixBus)	No tags

Next departures for Pittsburgh to San Diego on December 18
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
Greyhound Lines, Inc. + FlixBus	Bus	1:35am	Pittsburgh Intermodal Station	2d 15h	1:40pm	UCSD Health La Jolla Station	Cheapest
Greyhound Lines, Inc. + FlixBus	Bus	10:50am	Pittsburgh Intermodal Station	2d 9h	5:35pm	UCSD Health La Jolla Station	Fastest
Greyhound Lines, Inc. + FlixBus	Bus	1:35am	Pittsburgh Intermodal Station	2d 15h	2:10pm	San Diego (Old Town-FlixBus)	No tags
	Bus	10:50am	Pittsburgh Intermodal Station	2d 9h	5:45pm	Greyhound Bus Stop	No tags
Greyhound Lines, Inc. + FlixBus	Bus	10:50am	Pittsburgh Intermodal Station	2d 10h	6:10pm	San Diego (Old Town-FlixBus)	No tags

Last refresh of the prices: Last Sunday at 4:14 AM EST.

Get from Pittsburgh to San Diego

This route is served by bus only

The journey takes about 2 days, 15 hours 5 minutes, and with fares starting at just $371, it presents an excellent value for a comfortable ride.

10bus per day

2d 15hAverage Duration

3403 kmDistance

85kgCO₂ emissions

Where are the popular stops in Pittsburgh and San Diego?

Stops in Pittsburgh

A
Intermodal Station
55 11th St, Pittsburgh, PA 15222, USA
Visit page
B
Sennott Square
201 S Bouquet St, Pittsburgh, PA 15213, USA

Stops in San Diego

A
Mission Valley Sheraton
1433 Camino del Rio S, San Diego, CA 92108, USA
B
Old Town Courtyard Marriot
2435 Jefferson St, San Diego, CA 92110, USA
C
Downtown Holiday Inn
1617 1st Ave, San Diego, CA 92101, USA
D
Greyhound Station
1313 National Ave, San Diego, CA 92101, USA
E
Market St. & Park Blvd
601 Park Boulevard, San Diego, CA 92101, USA
F
San Ysidro McDonald's
727 E San Ysidro Blvd, San Diego, CA 92173, USA

Compare bus companies

Greyhound

3.5/587,430 reviews

Staff3.6

Timeliness2.9

Cleanliness3.3

Wifi2.4

Based on 87430 reviews, the company was rated 3.5 stars on Busbud. Travellers were especially satisfied with the ticket access and the temperature but often complained with the WiFi. Greyhound ticket prices on this trip start at $422

US Bus Companies: FlixBus, BlaBlaCar Bus, ALSA, Greyhound, Intercape, Trenitalia, Big Sky

Frequently asked questions about travelling from Pittsburgh to San Diego, CA, US by bus

Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.

How much is the bus ticket from Pittsburgh to San Diego?
The cheapest bus tickets from Pittsburgh to San Diego start from $371. The average price for this route is around $508. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Pittsburgh to San Diego?
The average bus travel time from Pittsburgh to San Diego is 2d 15h, covering a distance of 3403 km. The quickest bus can get you there in 2d 9h and is operated by Greyhound.
Which bus companies service the Pittsburgh to San Diego route?
Several major bus companies operate on this route with 10 buses available per day.
What are the earliest and latest departure times for the bus from Pittsburgh to San Diego?
The earliest bus departs from Pittsburgh to San Diego at 1:35am. And the latest bus departs at 8:00pm.
What are the CO₂ emissions for the bus trip from Pittsburgh to San Diego?
A bus trip from Pittsburgh to San Diego generates an estimated 85 kg of CO₂, making it a highly eco-friendly travel option and a mode of travel recommended by Busbud.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found

12-11

$755

12-12

$571

Today

$688

12-14

$464

12-15

$651

12-16

$552

12-17

$550

12-18

$684

The cheapest trip from Pittsburgh to San Diego, CA, US was searched and found on Dec 14, 2025 with a price of $464

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Pittsburgh to San Diego, CA, US, as early as possible.

You can expect to pay from $464 to $755 for a bus ticket from Pittsburgh to San Diego, CA, US based on the last 2 days. You can expect to find the cheapest price for the trip at $464 which is on 2025-12-14.