Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
Greyhound Lines, Inc. + FlixBus | Bus | Roanoke Bus Stop | Chicago 95Th & Dan Ryan | Cheapest | ||||
 | Bus | Roanoke Bus Stop | 537-517 W. Jackson Blvd | Fastest | ||||
| Bus | Roanoke Bus Stop | Downtown Greyhound Station | No tags |
Last refresh of the prices: Last Thursday at 6:11 PM EST.
Compare 2 ways to go from Roanoke to Chicago
Among the sustainable travel choices, the bus stands out as a good way to reach Chicago. The journey takes about 22 hours, and with fares starting at just $155, it presents an excellent value for a comfortable ride.
Where are the popular stops in Roanoke and Chicago?
Stops in Roanoke
- AExit 140 (Park and Ride), Virginia 24153, USA
Stops in Chicago
- A630 W Harrison St, Chicago, IL 60607, USA
- C
Polk St & Canal St
500-536 W Polk St, Chicago IL 60607, USA - D
Tornado Bus S Kedzie Ave
2807 S Kedzie Ave, Chicago, IL 60623, USA - E
Cumberland CTA
5800 N Cumberland Ave, Chicago, IL 60631, USA - F
Turimex California Ave
2139 S California Ave, Chicago, IL 60608, USA
Compare bus companies
Based on 87431 reviews, the company was rated 3.5 stars on Busbud. Travellers were especially satisfied with the ticket access and the temperature but often complained with the WiFi. Greyhound ticket prices on this trip start at $160
Frequently asked questions about travelling from Roanoke to Chicago by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from Roanoke to Chicago?
The cheapest bus tickets from Roanoke to Chicago start from $155. The average price for this route is around $266. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Roanoke to Chicago?
The average bus travel time from Roanoke to Chicago is 22h, covering a distance of 835 km. The quickest bus can get you there in 20h and is operated by Greyhound.
Which bus companies service the Roanoke to Chicago route?
Several major bus companies operate on this route with 5 buses available per day.
What are the earliest and latest departure times for the bus from Roanoke to Chicago?
The earliest bus departs from Roanoke to Chicago at 4:35am. And the latest bus departs at 12:50pm.
What are the CO₂ emissions for the bus trip from Roanoke to Chicago?
A bus trip from Roanoke to Chicago generates an estimated 21 kg of CO₂, making it a highly eco-friendly travel option and a mode of travel recommended by Busbud.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Roanoke to Chicago was searched and found on Dec 17, 2025 with a price of $164To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Roanoke to Chicago, as early as possible.
You can expect to pay from $164 to $413 for a bus ticket from Roanoke to Chicago based on the last 2 days. You can expect to find the cheapest price for the trip at $164 which is on 2025-12-17.
What's the cheapest way to go from Roanoke to Chicago?
The bus is the cheapest travel choice for this destination
