Previously seen trips
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
Greyhound + FlixBus | Bus | Roanoke Bus Stop | Downtown Transit Center | No tags | ||||
 | Bus | Roanoke Bus Stop | Indianapolis Bus Station | No tags | ||||
| Bus | Roanoke Bus Stop | Indianapolis Bus Station | No tags | ||||
FlixBus + Greyhound | Bus | Roanoke Bus Stop | Downtown Transit Center | No tags | ||||
Greyhound + FlixBus | Bus | Roanoke Bus Stop | Downtown Transit Center | No tags |
Compare 2 ways to go from Roanoke to Indianapolis
Among the sustainable travel choices, the train stands out as a good way to reach Indianapolis. The journey takes about 20 hours 37 minutes, and with fares starting at just $135, it presents an excellent value for a comfortable ride.
Where are the popular stops in Roanoke and Indianapolis?
Stops in Roanoke
- AExit 140 (Park and Ride), Virginia 24153, USA
Compare bus companies
Based on 87386 reviews, the company was rated 3.5 stars on Busbud. Travellers were especially satisfied with the ticket access and the temperature but often complained with the WiFi. Greyhound ticket prices on this trip start at $95
Greyhound Roanoke Indianapolis recent customer reviews
It was way too cramped...totally sore after this trip
Danny C.
Frequently asked questions about travelling from Roanoke to Indianapolis by bus
What is the travel distance from Roanoke to Indianapolis?
The distance between Roanoke and Indianapolis is around 609 km (378 miles).
What are the departure and arrival locations for buses traveling from Roanoke to Indianapolis?
Buses traveling this route start their trip at Salem - Exit 140 Park & Ride, in Roanoke, and end it at Greyhound Amtrak Station, in Indianapolis.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Roanoke to Indianapolis was searched and found on Nov 19, 2025 with a price of $213To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Roanoke to Indianapolis, as early as possible.
What's the cheapest way to go from Roanoke to Indianapolis?
The bus is the cheapest travel choice for this destination
