Previously seen trips
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
Greyhound + FlixBus | Bus | Roanoke Bus Stop | Downtown Transit Center | No tags | ||||
 | Bus | Roanoke Bus Stop | Indianapolis Bus Station | No tags | ||||
| Bus | Roanoke Bus Stop | Indianapolis Bus Station | No tags | ||||
FlixBus + Greyhound | Bus | Roanoke Bus Stop | Downtown Transit Center | No tags | ||||
Greyhound + FlixBus | Bus | Roanoke Bus Stop | Downtown Transit Center | No tags |
Compare 2 ways to go from Roanoke to Indianapolis
Among the sustainable travel choices, the train stands out as the good way to reach Indianapolis. The journey takes about 20 hours 37 minutes and with fares starting at just $94, it presents an excellent value for a comfortable ride.
Compare bus companies
Greyhound Lines offers the most comprehensive intercity bus services in the United States. They operate a modern, environmentally friendly fleet that serves more than 2400 destinations and carries nearly 16 million passengers annually. When traveling with them, you can expect free WiFi, onboard entertainment, bathrooms, power outlets and decent legroom. One of the great perks of Greyhound is that they connect big cities and smaller towns in the US, where you usually can't get to by train or plane. If you're looking for safe and affordable transportation, Greyhound is a great choice.
Greyhound Roanoke Indianapolis recent customer reviews
It was way too cramped...totally sore after this trip
Danny C.
Where are the popular stops in Roanoke and Indianapolis?
Frequently asked questions about traveling from Roanoke to Indianapolis by bus
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Roanoke to Indianapolis was searched and found on Nov 19, 2025 with a price of $147To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Roanoke to Indianapolis, as early as possible.
What's the cheapest way to go from Roanoke to Indianapolis?
The bus is the cheapest travel choice for this destination
