Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
Greyhound Lines, Inc. + FlixBus | Bus | Roanoke Bus Stop | Downtown Transit Center | Cheapest | ||||
 | Bus | Roanoke Bus Stop | Indianapolis Bus Station | Fastest | ||||
| Bus | Roanoke Bus Stop | Indianapolis Bus Station | No tags | ||||
Greyhound Lines, Inc. + FlixBus | Bus | Roanoke Bus Stop | Downtown Transit Center | No tags |
Last refresh of the prices: Last Thursday at 12:18 PM EST.
Compare 2 ways to go from Roanoke to Indianapolis
Among the sustainable travel choices, the Train stands out as a good way to reach Indianapolis. The journey takes about 21 hours 17 minutes and with fares starting at just $90, it presents an excellent value for a comfortable ride.
Where are the popular stops in Roanoke and Indianapolis?
Stops in Roanoke
- AExit 140 (Park and Ride), Virginia 24153, USA
Compare bus companies
Greyhound Lines offers the most comprehensive intercity bus services in the United States. They operate a modern, environmentally friendly fleet that serves more than 2400 destinations and carries nearly 16 million passengers annually. When traveling with them, you can expect free WiFi, onboard entertainment, bathrooms, power outlets and decent legroom. One of the great perks of Greyhound is that they connect big cities and smaller towns in the US, where you usually can't get to by train or plane. If you're looking for safe and affordable transportation, Greyhound is a great choice.
Greyhound Roanoke Indianapolis recent customer reviews
It was way too cramped...totally sore after this trip
Danny C.
Frequently asked questions about traveling from Roanoke to Indianapolis by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from Roanoke to Indianapolis?
The cheapest bus tickets from Roanoke to Indianapolis start from $93. The average price for this route is around $112. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Roanoke to Indianapolis?
The average bus trip duration from Roanoke to Indianapolis is 19h 35m, covering a distance of 377 miles (608 km). The quickest bus can get you there in 15h 55m and is operated by Greyhound.
Which bus companies service the Roanoke to Indianapolis route?
Several major bus companies operate on this route with 4 buses available per day.
What is the earliest and latest departure time for the bus from Roanoke to Indianapolis?
The earliest bus departs from Roanoke to Indianapolis at 4:35am. And the latest bus departs at 12:50pm.
What are the CO₂ emissions for the bus trip from Roanoke to Indianapolis?
A bus trip from Roanoke to Indianapolis generates an estimated 15 kg of CO₂, making it a highly eco-friendly travel option and recommended mode of travel by Busbud.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Roanoke to Indianapolis was searched and found on Mar 1, 2026 with a price of $106To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Roanoke to Indianapolis, as early as possible.
You can expect to pay from $106 to $245 for a bus ticket from Roanoke to Indianapolis based on the last 2 days. You can expect to find the cheapest price for the trip at $130 which is on 2026-03-03.
