Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Rome Tiburtina Bus Station | Brussels-South (Gare du Midi) | Cheapest | ||||
 | Bus | Rome Tiburtina Bus Station | Brussels North Train Station | Fastest | ||||
| Bus | Rome Tiburtina Bus Station | Brussels North Train Station | No tags | ||||
| Bus | Rome Tiburtina Bus Station | Brussels North Train Station | No tags | ||||
| Bus | Rome Tiburtina Bus Station | Brussels North Train Station | No tags | ||||
| Bus | Rome Tiburtina Bus Station | Brussels North Train Station | No tags | ||||
| Bus | Rome Tiburtina Bus Station | Brussels South (Gare du Midi) | No tags | ||||
| Bus | Rome Tiburtina Bus Station | Brussels South (Gare du Midi) | No tags |
Last refresh of the prices: Yesterday at 1:48 AM CEST.
Get from Rome to Brussels
The journey takes about 1 day, 6 hours 55 minutes, and with fares starting at just COP 276,129, it presents an excellent value for a comfortable ride.
Where are the popular stops in Rome and Brussels?
Stops in Rome
- A
Rome Tiburtina Bus Station
Largo Guido Mazzoni, 3, 00162 Roma, Italy - D
Castro Pretorio
Viale Castro Pretorio 76, 00185 Roma, Italy - E
Roma
- F
Anagnina
Via Vincenzo Giudice, 00173 Roma RM, Italy
Stops in Brussels
- A
Brussels South (Gare du Midi)
Rue de France 85, 1060 Saint-Gilles, Belgium - B
Brux-Nord
Boulevard Simon Bolivar 7, 1030 Schaerbeek, Belgium - C
Centrale
Rue de Loxum 5, 1000 Bruxelles, Belgium - D
Congrès
Pachecolaan 5, 1000 Brussel, Belgium
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Frequently asked questions about travelling from Rome to Brussels by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from Rome to Brussels?
The cheapest bus tickets from Rome to Brussels start from COP 276,129. The average price for this route is around COP 512,089. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Rome to Brussels?
The average bus travel time from Rome to Brussels is 1d 6h, covering a distance of 1178 km. The quickest bus can get you there in 22h 30m and is operated by FlixBus.
Which bus companies service the Rome to Brussels route?
Several major bus companies operate on this route with 37 buses available per day, including services from FlixBus, BlaBlaCar Bus, RegioJet.
What are the earliest and latest departure times for the bus from Rome to Brussels?
The earliest bus departs from Rome to Brussels at 12:20am. And the latest bus departs at 11:50pm.
What are the CO₂ emissions for the bus trip from Rome to Brussels?
A bus trip from Rome to Brussels generates an estimated 29.4488 kg of CO₂, making it a highly eco-friendly travel option and a mode of travel recommended by Busbud.
What is the best bus company from Rome to Brussels?
According to Busbud customers, the highest-rated bus company on this route is RegioJet, with an average rating of 4.1 out of 5 stars based on 1080 reviews.
Which bus company has the best Wi-Fi from Rome to Brussels?
Based on Busbud reviews, the bus company RegioJet has the highest Wi-Fi rating with a score of 3.9.
Which bus company has the best on-time performance from Rome to Brussels?
According to Busbud traveller reviews, the most punctual bus company on this route is RegioJet, with a punctuality rating of 4.0 out of 5 stars.
Which bus company has the cleanest buses from Rome to Brussels?
According to Busbud traveller reviews, the bus company with the cleanest buses on this route is RegioJet, with a cleanliness rating of 4.4 out of 5 stars.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Rome to Brussels was searched and found on Jul 8, 2026 with a price of COP 313,533To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Rome to Brussels, as early as possible.
You can expect to pay from COP 313,533 to COP 1,084,515 for a bus ticket from Rome to Brussels based on the last 2 days. You can expect to find the cheapest price for the trip at COP 313,533 which is on 2026-07-08.
