Next departures for Rome to Brussels on November 20
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Bus
Rome Tiburtina Bus Station
Brussels North Train Station
Cheapest
Bus
Rome Tiburtina Bus Station
Brussels North Train Station
Fastest
Bus
Rome Tiburtina Bus Station
Brussels North Train Station
No tags
Bus
Rome Tiburtina Bus Station
Brussels North Train Station
No tags
Bus
Rome Tiburtina Bus Station
Brussels North Train Station
No tags
Next departures for Rome to Brussels on November 26
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Bus
Rome Tiburtina Bus Station
Brussels North Train Station
CheapestFastest
Bus
Rome Tiburtina Bus Station
Brussels-South (Gare du Midi)
No tags
Bus
Rome Tiburtina Bus Station
Brussels North Train Station
No tags
Bus
Rome Tiburtina Bus Station
Brussels North Train Station
No tags
Bus
Rome Tiburtina Bus Station
Brussels North Train Station
No tags
Last refresh of the prices: Today at 4:11 PM CET.
Compare 2 ways to go from Rome to Brussels
We recommend carpooling
Among the sustainable travel choices, the carpool stands out as the good way to reach Brussels. The journey takes about 15 hours and with fares starting at just $145, it presents an excellent value for a comfortable ride.
Flixbus is a European bus operator that offers intercity and bus travel in over 38 countries. Known for their easy-to-spot lime green buses and for offering affordable transportation between cities in Europe and the Americas, Flixbus is a good option for those looking for an affordable, reliable bus company. In their buses, you'll find free WiFi, bathrooms, and power outlets. You can also pay extra to choose your seat and get extra legroom, or even buy a snack or drink onboard directly from the driver. You can reschedule your ticket for a small fee, which varies from $1 to $5, depending on how close you are to the departure date.
Based on 11142 reviews, the company was rated 3.7 stars on Busbud. Travelers were especially satisfied with the ticket access and the staff but often complained with the wifi. BlaBlaCar Bus ticket prices on this trip start at $102
Frequently asked questions about traveling from Rome to Brussels by bus
How far is Rome from Brussels?
About 729 miles (1175 km) separate Rome and Brussels.
What are the departure and arrival stations when taking the bus from Rome to Brussels?
Most of the buses traveling from Rome to Brussels leave from Rome Tiburtina Bus Station and arrive at Brussels South (Gare du Midi). These are the main departure and arrival locations on this route, there are other pick-up and drop-off locations that could make it easier for you to reach your destination.
What are the best sights and things to do in Brussels?
Once in Brussels, you can start exploring the city and discover its surroundings. The top sights and things to do are Fête de la Musique, Couleur Café Music Festival, Fête de la BD - Comic Festival in Brussels! Le Tour - Brussels Grand Départ and Belgian Beer Weekend in Brussels!
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
Best price found
11/17
$125
11/18
No data
Today
No data
11/20
$94
11/21
$82
11/22
No data
11/23
No data
11/24
No data
The cheapest trip from Rome to Brussels was searched and found on Nov 21, 2025 with a price of $82
To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Rome to Brussels, as early as possible.
You can expect to pay from $82 to $215 for a bus ticket from Rome to Brussels based on the last 2 days. You can expect to find the cheapest price for the trip at $82 which is on 2025-11-21.
The cheapest trip from Rome to Brussels was searched and found on Nov 21, 2025 with a price of $82
