Bus Tickets from Santa Fe to Santo Tomé

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TodayMay 16
from US$41
TomorrowMay 17
SunMay 18
MonMay 19
TueMay 20
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ThuMay 22
FriMay 23

Cheap buses leaving today

One passenger / one way

  • This trip is recommended because it is the: Cheapest + Fastest
    Departure time: May 16 at
    Departure city: Santa Fe
    Departure location: Estación Terminal de Ómnibius, Santa Fe
    Arrival time: May 17 at
    Destination city: Santo Tomé
    Destination location: Esso Santo Tome
    Operated by: Expreso SingerExpreso Singer
    Vehicle: BusDuration:

Last refresh of the prices: Last Tuesday at 8:32 AM -03.

Prices and availability are subject to change.

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Bus Santa Fe to Santo Tomé: Trip Overview

Average Ticket PriceUS$50
Average Bus Trip Duration8h 5m
Number of daily buses2
Earliest bus departure1:15am
Distance559 km
Latest bus departure9:10pm

Santa Fe to Santo Tomé Bus

Busbud shows you the best bus ticket fares and bus schedules so you can easily plan and book a trip by bus from Santa Fe to Santo Tomé.

We make sure you can find a bus service from Santa Fe to Santo Tomé from the most reliable bus companies operating this trip.

From cheap bus tickets to more luxurious buses travelling from Santa Fe to Santo Tomé, we offer a wide range of bus services to best suit your needs depending on how much your budget is.

Frequently asked questions on the trip Santa Fe - Santo Tomé

  1. How long is the bus ride from Santa Fe to Santo Tomé?

    The typical travel time from Santa Fe to Santo Tomé by bus is around 8h 5m. For the shortest travel time, select the fastest bus available, which will take you to Santo Tomé in about 8h 5m.

  2. How far is Santa Fe from Santo Tomé?

    The distance between Santa Fe and Santo Tomé is approximately 565 km (350 miles).

  3. What are the departure and arrival locations for buses traveling from Santa Fe to Santo Tomé?

    Buses departing from Estación Terminal de Ómnibius, Santa Fe in Santa Fe will take you to Esso Santo Tome in Santo Tomé.

  4. What is the cheapest way to get from Santa Fe to Santo Tomé?

    The least expensive way to go from Santa Fe to Santo Tomé would be going by bus. With a starting ticket price of US$50, this bus becomes your top pick for this journey.

  5. How much does it cost to take the bus from Santa Fe to Santo Tomé?

    You can expect to pay around US$50 for the bus ride from Santa Fe to Santo Tomé.

  6. Can I take an overnight bus from Santa Fe to Santo Tomé?

    Yes! If you're heading from Santa Fe to Santo Tomé, you'll find buses departing until 9:10pm and arriving the next day.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
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US$38
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busbud logoThe cheapest trip from Santa Fe to Santo Tomé was searched and found on May 16, 2025 with a price of US$38

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Santa Fe to Santo Tomé, as early as possible.

About Bus Travel

Bus Travel Tips

If you're abroad, study some local language. Not only could it get you out of a pickle during your bus trip from Santa Fe to Santo Tomé but it'll also be endearing to native speakers who will surely appreciate your effort.

Start sightseeing the minute your bus leaves the station. If you're on the night bus from Santa Fe to Santo Tomé, get comfy and count the stars.

Taking the bus creates the smallest carbon footprint compared to other modes of transport. Not to mention that buses will allow you to discover scenic gems from Santa Fe to Santo Tomé that are otherwise impossible to come by with a plane.

Tune out to the fine sounds of your best music playlist on your bus trip from Santa Fe to Santo Tomé while indulging in miles on end of beautiful scenic views.

Did you know?

9.2% of ground transportation in Europe is done by bus versus 7.4% by train.

It takes 27 hours to go by bus from Lima to Cusco, one of the craziest bus trips on the world. This route is used daily by locals and backpackers.

Did you know some bus companies in Germany offer to their passenger low-costs snacks and regional beer based on their destination? Prosit!

Will you be returning to Santa Fe by bus?

Bus from Santa Fe to Santo Tomé

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