Bus Tickets from Santa Fe to Santo Tomé

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TodayMay 8
TomorrowMay 9
SatMay 10
SunMay 11
from $49
MonMay 12
TueMay 13
WedMay 14
ThuMay 15

Cheap buses leaving Sunday

One passenger / one way

  • This trip is recommended because it is: Cheapest + Fastest
    Departure time: May 11 at
    Departure city: Santa Fe
    Departure location: Estación Terminal de Ómnibius, Santa Fe
    Arrival time: May 12 at
    Destination city: Santo Tomé
    Destination location: Esso Santo Tome
    Operated by: Expreso SingerExpreso Singer
    Vehicle: BusDuration:
  • Departure time: May 11 at
    Departure city: Santa Fe
    Departure location: Estación Terminal de Ómnibius, Santa Fe
    Arrival time: May 11 at
    Destination city: Santo Tomé
    Destination location: Esso Santo Tome
    Operated by: La 20 de JunioLa 20 de Junio
    Vehicle: BusDuration:
  • Departure time: May 11 at
    Departure city: Santa Fe
    Departure location: Estación Terminal de Ómnibius, Santa Fe
    Arrival time: May 11 at
    Destination city: Santo Tomé
    Destination location: Esso Santo Tome
    Operated by: La 20 de JunioLa 20 de Junio
    Vehicle: BusDuration:

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Bus Santa Fe to Santo Tomé: Trip Overview

Average ticket price$50
Average bus trip duration8h 5m
Number of daily buses2
Earliest bus departure1:15am
Distance347 miles (559 km)
Latest bus departure9:10pm

Santa Fe to Santo Tomé Bus

Busbud shows you the best bus ticket fares and bus schedules so you can easily plan and book a trip by bus from Santa Fe to Santo Tomé.

We make sure you can find a bus service from Santa Fe to Santo Tomé from the most reliable bus companies operating this trip.

From cheap bus tickets to more luxurious buses traveling from Santa Fe to Santo Tomé, we offer a wide range of bus services to best suit your needs depending on how much your budget is.

Frequently asked questions for your trip Santa Fe - Santo Tomé

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
05/06
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05/07
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Today
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05/09
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05/10
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05/11
$47
05/12
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05/13
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busbud logoThe cheapest trip from Santa Fe to Santo Tomé was searched and found on May 11, 2025 with a price of $47

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Santa Fe to Santo Tomé, as early as possible.

You can expect to pay from $47 to $70 for a bus ticket from Santa Fe to Santo Tomé based on the last 2 days. You can expect to find the cheapest price for the trip at $47 which is on 2025-05-11.

Usually La 20 de Junio will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.

About Bus Travel

Bus Travel Tips

If you're abroad, study some local language. Not only could it get you out of a pickle during your bus trip from Santa Fe to Santo Tomé but it'll also be endearing to native speakers who will surely appreciate your effort.

Start sightseeing the minute your bus leaves the station. If you're on the night bus from Santa Fe to Santo Tomé, get comfy and count the stars.

Taking the bus creates the smallest carbon footprint compared to other modes of transport. Not to mention that buses will allow you to discover scenic gems from Santa Fe to Santo Tomé that are otherwise impossible to come by with a plane.

Tune out to the fine sounds of your best music playlist on your bus trip from Santa Fe to Santo Tomé while indulging in miles on end of beautiful scenic views.

Did you know?

9.2% of ground transportation in Europe is done by bus versus 7.4% by train.

It takes 27 hours to go by bus from Lima to Cusco, one of the craziest bus trips on the world. This route is used daily by locals and backpackers.

Did you know some bus companies in Germany offer to their passenger low-costs snacks and regional beer based on their destination? Prosit!

Will you be returning to Santa Fe by bus?

Bus from Santa Fe to Santo Tomé

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