Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
Greyhound Lines, Inc. + FlixBus | Bus | Spartanburg | Chicago 95Th & Dan Ryan | Cheapest | ||||
Greyhound Lines, Inc. + FlixBus | Bus | Spartanburg | Chicago 95Th & Dan Ryan | Fastest | ||||
Greyhound Lines, Inc. + FlixBus | Bus | Spartanburg | Downtown Greyhound Station | No tags | ||||
 | Bus | Spartanburg | Downtown Greyhound Station | No tags | ||||
FlixBus + Greyhound Lines, Inc. | Bus | Spartanburg | Downtown Greyhound Station | No tags |
Last refresh of the prices: Yesterday at 8:56 AM EST.
Compare 2 ways to go from Spartanburg to Chicago
Among the sustainable travel choices, the bus stands out as a good way to reach Chicago. The journey takes about 20 hours 30 minutes, and with fares starting at just $171, it presents an excellent value for a comfortable ride.
Where are the popular stops in Spartanburg and Chicago?
Stops in Spartanburg
- A9133 Fairforest Rd. Spartanburg, SC , C.P. 29301
- B
Spartanburg Bus Stop
1402 E Main St, Spartanburg, SC 29307, USA - C
Sparta Passenger Center
100 Liberty St, Spartanburg, SC 29306, USA
Stops in Chicago
- A630 W Harrison St, Chicago, IL 60607, USA
- C
Polk St & Canal St
500-536 W Polk St, Chicago IL 60607, USA - D
Tornado Bus S Kedzie Ave
2807 S Kedzie Ave, Chicago, IL 60623, USA - E
Cumberland CTA
5800 N Cumberland Ave, Chicago, IL 60631, USA - F
Turimex California Ave
2139 S California Ave, Chicago, IL 60608, USA
Compare bus companies
Frequently asked questions about travelling from Spartanburg to Chicago by bus
How far is Spartanburg from Chicago?
Spartanburg and Chicago are 916 km (568 miles) apart.
What are the departure and arrival locations for buses traveling from Spartanburg to Chicago?
Buses departing from Super Acapulco in Spartanburg will take you to Downtown Greyhound Station in Chicago.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Spartanburg to Chicago was searched and found on Nov 26, 2025 with a price of $183To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Spartanburg to Chicago, as early as possible.
You can expect to pay from $183 to $297 for a bus ticket from Spartanburg to Chicago based on the last 2 days. You can expect to find the cheapest price for the trip at $183 which is on 2025-11-26.
What's the cheapest way to go from Spartanburg to Chicago?
The bus is the cheapest travel choice for this destinationTop travelled bus routes
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Popular bus departures from Spartanburg
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