Trains leaving Saturday
One passenger / one way
- This trip is recommended because it is the: Cheapest + FastestDeparture time: June 28 atDeparture city: BuffaloDeparture location: Depew StationArrival time: June 28 atDestination city: St LouisDestination location: Gateway StationOperated by: Amtrak
Vehicle: TrainDuration: - Departure time: June 28 atDeparture city: BuffaloDeparture location: Depew StationArrival time: June 28 atDestination city: St LouisDestination location: Gateway StationOperated by: AmtrakVehicle: TrainDuration:
- Departure time: June 28 atDeparture city: BuffaloDeparture location: Depew StationArrival time: June 29 atDestination city: St LouisDestination location: Gateway StationOperated by: AmtrakVehicle: TrainDuration:
- Departure time: June 28 atDeparture city: BuffaloDeparture location: Depew StationArrival time: June 29 atDestination city: St LouisDestination location: Gateway StationOperated by: AmtrakVehicle: TrainDuration:
- Departure time: June 28 atDeparture city: BuffaloDeparture location: Depew StationArrival time: June 29 atDestination city: St LouisDestination location: Gateway StationOperated by: AmtrakVehicle: TrainDuration:
Last refresh of the prices: Last Saturday at 10:03 AM EDT.
Prices and availability are subject to change.
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Compare 2 ways to go from Buffalo to St Louis
Busbud recommends taking the train from Buffalo to St LouisAmong the sustainable travel choices, the train stands out as a good way to reach St Louis. The journey takes about 19 hours 28 minutes, and with fares starting at just US$128, it presents an excellent value for a comfortable ride.
Train Buffalo to St Louis: Trip Overview
Please note, this information is subject to change
Train companies
Based on 5233 reviews, the company was rated 4.1 stars on Busbud. Travellers were especially satisfied with the seats and the ticket access but often complained with the WiFi. Amtrak ticket prices on this trip start at US$128
Buffalo to St Louis Train
Busbud shows you the best train ticket fares and train schedules so you can easily plan and book a trip by train from Buffalo to St Louis.
We make it our job to connect you with the most dependable companies that offer train service from Buffalo to St Louis.
Whether it is train tickets or first class train tickets going to St Louis from Buffalo, we help you find what you're looking for based on how much of a budget you have.
Where are the popular train stations and stops in Buffalo, NY and St Louis?
Frequently asked questions on the trip Buffalo, NY - St Louis
How much does a cheap train ticket from Buffalo to St Louis cost?
The average train ticket price from Buffalo to St Louis is US$221. The best way to find cheap train tickets from Buffalo to St Louis is to book your tickets as early as possible. Prices tend to rise as your travel date approaches, so book in advance to secure the best prices!
How long is the trip from Buffalo to St Louis?
A train trip between Buffalo and St Louis is around 19h 28m, although the fastest train will take about 19h 28m. This is the time it takes to travel the 1065 km that separates the two cities.
How many daily trains are there between Buffalo and St Louis?
The number of trains from Buffalo to St Louis can differ depending on the day of the week. On average, there are 1.9499999999999997. Some trains are direct while others include transferring trains. Simplify your train trip from Buffalo to St Louis by comparing and selecting the train that fits your travel style and budget on Busbud.
Which train companies travel from Buffalo to St Louis?
When taking the train from Buffalo to St Louis, you can travel comfortably and safely with Amtrak.
Find cheapest prices for trains
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Buffalo to St Louis was searched and found on Jun 29, 2025 with a price of US$185To save money and be sure you have the best seat, it's a good idea to buy your train tickets from Buffalo to St Louis, as early as possible.
You can expect to pay from US$185 to US$1,670 for a train ticket from Buffalo to St Louis based on the last 2 days. You can expect to find the cheapest price for the trip at US$185 which is on 2025-06-29.
About Train Travel
Train Travel Tips
Do you like to go fast? With high-speed trains going faster than 300 km/h on certain routes, the time will fly by. Taking a train between Buffalo and St Louis is also a great way to travel to arrive in the city centre and save more time for your stay in St Louis.
Whether you take a regional or high-speed train to St Louis, you’ll help reduce the environmental impact and carbon footprint of your trip. As you watch the landscapes unfold before your eyes, you can tell yourself that with this choice, you are making sure they remain protected.
By choosing the train between Buffalo and St Louis, you emit up to 30 times less CO2 than for the same journey made by plane or car!
Tune out to the fine sounds of your best music playlist on your train trip from Buffalo to St Louis while indulging in miles on end of beautiful scenic views.
Did you know?
Railway companies played a major role as early as 1883 in the use of time zones as we know them today.
New York holds the record for the most platforms and track numbers in a single station. Grand Central Station in Manhattan is one of the largest rail terminals in the world with more than 44 platforms and 67 tracks to accommodate passengers.
You can find dogs as passengers on the trains of Moscow, where there is a large number of stray dogs. Over time, the dogs have learned the inner workings of the rail system and it is not uncommon to find one travelling between the city and the suburbs.
Top Travelled Train Routes
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