Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Brussels South (Gare du Midi) | Siena Train Station | Cheapest | ||||
| Bus | Brussels North Train Station | Siena Train Station | Fastest | ||||
| Bus | Brussels Airport | Siena Train Station | No tags | ||||
| Bus | Brussels Airport | Siena Train Station | No tags | ||||
| Bus | Brussels Airport | Siena Train Station | No tags |
Last refresh of the prices: Yesterday at 19:35 CET.
Get from Brussels to Siena
The journey takes about 1 day, 3 hours 49 minutes, and with fares starting at just £66, it presents an excellent value for a comfortable ride.
Where are the popular stops in Brussels and Siena?
Stops in Brussels
- ARue de France 85, 1060 Saint-Gilles, Belgium
- BBoulevard Simon Bolivar 7, 1030 Schaerbeek, Belgium
- CPachecolaan 5, 1000 Brussel, Belgium
- D
Centrale
Rue de Loxum 5, 1000 Bruxelles, Belgium
Stops in Siena
- APiazza Antonio Gramsci, 53100 Siena SI, Italy
- B
Via Sallustio Bandini, 21
Via Sallustio Bandini, 21, 53100 Siena SI, Italy - C
Via Giuseppe Mazzini, 58
Via Giuseppe Mazzini, 58, 53100 Siena SI, Italy - D
Via Riccardo Lombardi, 42
Via Riccardo Lombardi, 42, 53100 Siena SI, Italy - E
Torre Fiorentina
Torre Fiorentina, 53100 Siena SI, Italy - F
Siena Zona Industriale
Siena FS, 53100 Siena SI, Italy
Compare bus companies
Based on 11600 reviews, the company was rated 3.5 stars on Busbud. Travellers were especially satisfied with the ticket access and the staff but often complained with the Wi-Fi. FlixBus ticket prices on this trip start at £66
Frequently asked questions about travelling by bus from Brussels to Siena
Please note that timetables, routes, or operator details shown here may be updated or vary at the time of your journey.
How much is the bus ticket from Brussels to Siena?
The cheapest coach tickets from Brussels to Siena start from £66. The average price for this route is around £78. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus journey from Brussels to Siena?
The average bus journey time from Brussels to Siena is 1d 3h, covering a distance of 613 miles. The fastest bus can take you there in 20h 15m and is operated by FlixBus.
Which bus companies service the Brussels to Siena route?
Several major bus companies operate on this route with 15 buses available per day.
What is the earliest and latest departure time for the bus from Brussels to Siena?
The earliest bus departs from Brussels to Siena at 00:45. And the latest bus departs at 22:00.
What are the CO₂ emissions for the bus trip from Brussels to Siena?
A bus journey from Brussels to Siena produces an estimated 25 kg of CO₂, making it a highly eco-friendly choice and a mode of travel recommended by Busbud.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Brussels to Siena was searched and found on 17 Dec 2025 with a price of £62To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Brussels to Siena as early as possible.
You can expect to pay from £62 to £130 for a bus ticket from Brussels to Siena based on the last 2 days. You can expect to find the cheapest price for the trip at £62, which is on 2025-12-17.
