Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Harrisburg Bus Station | Bus station | CheapestFastest |
Last refresh of the prices: Yesterday at 00:06 EST.
Compare 2 ways to travel from Harrisburg to Florence
Among the sustainable travel choices, the train stands out as a good way to reach Florence. The journey takes about 14 hours 5 minutes and with fares starting at just £103, it presents an excellent value for a comfortable ride.
Where are the popular stops in Harrisburg and Florence?
Stops in Harrisburg
- A
Harrisburg Bieber Greyhound Station
411 Market St, Harrisburg, PA 17101
Stops in Florence
- A619 S Irby St, Florence, SC 29501, USA
- B
TA Travel Center - Florence
2301 W Lucas St, Florence, SC 29501, USA
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Frequently asked questions about travelling by bus from Harrisburg to Florence, SC, US
Please note that timetables, routes, or operator details shown here may be updated or vary at the time of your journey.
How much is the bus ticket from Harrisburg to Florence?
The cheapest coach tickets from Harrisburg to Florence start from £82. The average price for this route is around £128. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus journey from Harrisburg to Florence?
The average bus journey time from Harrisburg to Florence is 20h 55m, covering a distance of 448 miles. The fastest bus can take you there in 17h 20m and is operated by FlixBus.
Which bus companies service the Harrisburg to Florence route?
What is the earliest and latest departure time for the bus from Harrisburg to Florence?
The earliest bus departs from Harrisburg to Florence at 12:30. And the latest bus departs at 23:20.
What are the CO₂ emissions for the bus trip from Harrisburg to Florence?
A bus journey from Harrisburg to Florence produces an estimated 18 kg of CO₂, making it a highly eco-friendly choice and a mode of travel recommended by Busbud.
Which is the best bus company from Harrisburg to Florence?
According to Busbud customers, the highest-rated bus company on this route is Greyhound, with an average rating of 3.5 out of 5 stars based on 87463 reviews.
Which company has the best Wi-Fi from Harrisburg to Florence?
Based on Busbud reviews, the bus company FlixBus has the best Wi-Fi rating with a score of 2.7.
Which bus company offers the most punctual service from Harrisburg to Florence?
According to Busbud traveller reviews, the most punctual bus company on this route is FlixBus, with a punctuality rating of 3.9 out of 5 stars.
Which bus company has the cleanest buses from Harrisburg to Florence?
According to Busbud traveller reviews, the bus company with the cleanest buses on this route is FlixBus, with a cleanliness rating of 4.1 out of 5 stars.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Harrisburg to Florence, SC, US was searched and found on 3 Jan 2026 with a price of £105To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Harrisburg to Florence, SC, US as early as possible.
What's the cheapest way to go from Harrisburg to Florence, SC, US?
The bus is the cheapest travel choice for this destination
