Find coaches from Harrisburg to Florence, SC, US

Next departures

Next departures from Harrisburg to Florence on 3 November
Operated byVehicle typeDeparture timeDeparture locationTrip durationArrival timeArrival locationRecommendedPrice and booking link
FlixBus + Greyhound Lines, Inc.
    		Harrisburg Bus Station
    		Bus stationCheapestFastest

    Last refresh of the prices: 26/10/2025 EDT.

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    Compare 2 ways to travel from Harrisburg to Florence

    We recommend taking the train

    Among the sustainable travel choices, the train stands out as a good way to reach Florence. The journey takes about 14 hours 5 minutes and with fares starting at just US$172, it presents an excellent value for a comfortable ride.

    1train per day
    14h 5mAverage duration
    447 milesDistance
    66kgCO₂ emissions
    Bus
    		Average priceUS$77 - US$234Average duration22h 5m
    18kg CO₂e
    Train
    		Average priceUS$172 - US$343Average duration14h 5m
    66kg CO₂e

    Bus Harrisburg to Florence, SC, US: Trip Overview

    Average ticket priceUS$150
    Average bus trip duration22h 5m
    Number of daily buses2
    Earliest bus departure12:25
    Distance448 miles
    Latest bus departure23:20

    Harrisburg to Florence Bus

    With Busbud, comparing and booking tickets for a bus from Harrisburg to Florence is a breeze. Browse through an extensive selection of bus fares and bus schedules to find the best deals.

    Bus service from Harrisburg to Florence will be provided by the most trusted bus companies.

    Discover how much the bus trip from Harrisburg to Florence will cost you. Use our filters and sorting features to find the cheapest bus tickets or luxury buses.

    Frequently asked questions on the trip Harrisburg - Florence, SC, US

    1. How far is Florence from Harrisburg by coach?

      The journey from Harrisburg to Florence by coach covers an approximate distance of 446 miles (718 km).

    2. What is the best way to go from Harrisburg to Florence without flying?

      To travel from Harrisburg to Florence without flying, you can take the coaches. Choosing the coach guarantees a comfortable and sustainable travel experience, allowing you to admire the views on your way to your destination. You might also find carpooling options to travel between the two cities.

    About Bus Travel

    Bus Travel Tips

    Meet and talk to locals at the bus stations while travelling from Harrisburg to Florence.There is no better way to get inside travel information while exploring a new city than to go straight to its people.

    Much more than a mere vehicle taking you from Harrisburg to Florence, riding the bus will expose you to some of the most stunning panoramas while enroute to your final bus stop.

    Buses have the smallest carbon footprint of all motorized transport modes. A bus going from Harrisburg to Florence will emit half the CO2 emitted by a train, and radically less than a car or an airplane.

    Make a music playlist for your bus ride from Harrisburg to Florence, and enjoy the scenery to tunes from your own personal soundtrack.

    Did you know?

    One of the longest bus route in the world goes all the way from Ontario to Alberta in Canada (with the same bus). This trip is 3,435 km or 2,135 miles long and the price is a bit under $100.

    The word 'bus' is an abbreviation of 'omnibus" which means 'for all' in Latin as buses were meant to be transportation for everybody.

    Did you know there are on average 4,400 intercity bus departures every day in the US only? This number has been growing for 9 years in a row, yay!

    What's the cheapest way to go from Harrisburg to Florence, SC, US?

    busbud logoThe bus is the cheapest travel choice for this destination

    Will you be returning to Harrisburg by bus?

    Bus from Florence, SC, US to Harrisburg

    You can also go to Florence, SC, US by train

    Train from Harrisburg to Florence, SC, US

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