Next departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
FlixBus + Greyhound Lines, Inc. | Harrisburg Bus Station | Bus station | CheapestFastest |
Last refresh of the prices: 2025-10-26 EDT.
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Compare 2 ways to go from Harrisburg to Florence
Among the sustainable travel choices, the train stands out as a good way to reach Florence. The journey takes about 14 hours 5 minutes, and with fares starting at just US$172, it presents an excellent value for a comfortable ride.
Bus Harrisburg to Florence, SC, US: Trip Overview
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Harrisburg to Florence Bus
With Busbud, comparing and booking tickets for a bus from Harrisburg to Florence is a breeze. Browse through an extensive selection of bus fares and bus schedules to find the best deals.
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Where are the popular stops in Harrisburg and Florence?
Frequently asked questions on the trip Harrisburg - Florence, SC, US
What is the distance between Harrisburg and Florence?
The distance between Harrisburg and Florence is approximately 718 km (446 miles).
What are the departure and arrival locations for buses traveling from Harrisburg to Florence?
Buses departing from Harrisburg Bieber Greyhound Station in Harrisburg will take you to Florence Bus Station in Florence.
About Bus Travel
Bus Travel Tips
Meet and talk to locals at the bus stations while travelling from Harrisburg to Florence.There is no better way to get inside travel information while exploring a new city than to go straight to its people.
Much more than a mere vehicle taking you from Harrisburg to Florence, riding the bus will expose you to some of the most stunning panoramas while enroute to your final bus stop.
Buses have one of the smallest carbon footprints of motorized transport modes. A bus going from Harrisburg to Florence will emit less CO2 than a car or an airplane.
Make a music playlist for your bus ride from Harrisburg to Florence, and enjoy the scenery to tunes from your own personal soundtrack.
Did you know?
One of the longest bus route in the world goes all the way from Ontario to Alberta in Canada (with the same bus). This trip is 3,435 km or 2,135 miles long and the price is a bit under $100.
The word 'bus' is an abbreviation of 'omnibus" which means 'for all' in Latin as buses were meant to be transportation for everybody.
Did you know there are on average 4,400 intercity bus departures every day in the US only? This number has been growing for 9 years in a row, yay!
What's the cheapest way to go from Harrisburg to Florence, SC, US?
The bus is the cheapest travel choice for this destinationTop travelled bus routes
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Busbud makes bus travel easy. We help travellers find a bus, plot routes, and book intercity bus tickets all over the world. With several language and currency options available, Busbud seeks to cater to international bus travellers no matter where they are in the world. With Busbud, you can buy tickets with confidence. We ensure that you make the most out of your bus trip by partnering up with reliable bus companies from all around the world such as Greyhound, Eurolines, ALSA, OUIBUS (BlaBlaBus), National Express and many others.
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Popular Buses Connecting Harrisburg
Buses Leaving from Harrisburg
- Bus from Harrisburg to Houston
- Bus Harrisburg - Baltimore
- Harrisburg - Temple
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- Bus Harrisburg - Chicago
- Harrisburg - Atlanta
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- Bus Harrisburg - Salt Lake City
- Harrisburg - Rockledge
- Bus from Harrisburg to Richmond
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- Harrisburg - New Orleans
- Bus from Harrisburg to Newark
- Bus Harrisburg - Dover
- Harrisburg - San Diego
Buses Going to Harrisburg
- Bus from Pittsburgh to Harrisburg
- Bus Baltimore - Harrisburg
- Houston - Harrisburg
- Bus from Orlando to Harrisburg
- Bus Philadelphia - Harrisburg
- Indianapolis - Harrisburg
- Bus from Allentown to Harrisburg
- Bus New Haven - Harrisburg
- Salt Lake City - Harrisburg
- Bus from Latrobe to Harrisburg
- Bus New York City - Harrisburg
- Lawrence - Harrisburg
- Bus from Lewistown to Harrisburg
- Bus Wilkes-Barre - Harrisburg
- Columbus - Harrisburg
Popular Buses Connecting Florence
Buses Leaving from Florence
- Bus from Florence to Kansas City
- Bus Florence - Kansas City
- Florence - Oklahoma City
- Bus from Florence to Houston
- Bus Florence - Jackson
- Florence - Montgomery
- Bus from Florence to New York City
- Bus Florence - Silver Spring
- Florence - Jackson
- Bus from Florence to Washington
- Bus Florence - Cincinnati
- Florence - Chicago
- Bus from Florence to Manchester
- Bus Florence - Jackson
- Florence - Columbus
Buses Going to Florence
- Bus from Syracuse to Florence
- Bus Manchester - Florence
- Columbus - Florence
- Bus from Columbus to Florence
- Bus Los Angeles - Florence
- Toronto - Florence
- Bus from New York City to Florence
- Bus Greensboro - Florence
- Orlando - Florence
- Bus from Portland to Florence
- Bus Boston - Florence
- Gainesville - Florence
- Bus from New Haven to Florence
- Bus Miami - Florence
- West Palm Beach - Florence
Popular routes in this country
- Bus from Washington to New York City
- Bus Boston - New York City
- New York City - Boston
- Bus from Philadelphia to New York City
- Bus Niagara Falls - New York City
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- Bus Baltimore - New York City
- Atlanta - Savannah
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- Bus New York City - Burlington
- Las Vegas - Los Angeles
- Bus from Detroit to Chicago
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- Miami - Orlando