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One passenger / one way
- This trip is recommended because it is: Cheapest
- This trip is recommended because it is: Fastest
- Departure time: August 24 atDeparture city: HarrisburgDeparture location: HarrisburgArrival time: August 25 atDestination city: FlorenceDestination location: Florence, SCOperated by: FlixBus
Vehicle: BusDuration:
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Compare 2 ways to go from Harrisburg to Florence.
Busbud recommends taking the bus from Harrisburg to FlorenceAmong the sustainable travel choices, the bus stands out as the good way to reach Florence. The journey takes about 21 hours 40 minutes and with fares starting at just $80, it presents an excellent value for a comfortable ride.
Bus Harrisburg to Florence, SC, US: Trip Overview
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Harrisburg to Florence Bus
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Frequently asked questions for your trip Harrisburg - Florence, SC, US
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Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Harrisburg to Florence, SC, US was searched and found on Aug 25, 2025 with a price of $93To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Harrisburg to Florence, SC, US, as early as possible.
You can expect to pay from $93 to $159 for a bus ticket from Harrisburg to Florence, SC, US based on the last 2 days. You can expect to find the cheapest price for the trip at $93 which is on 2025-08-25.
About Bus Travel
Bus Travel Tips
Meet and talk to locals at the bus stations while traveling from Harrisburg to Florence.There is no better way to get inside travel information while exploring a new city than to go straight to its people.
Much more than a mere vehicle taking you from Harrisburg to Florence, riding the bus will expose you to some of the most stunning panoramas while enroute to your final bus stop.
Buses have one of the smallest carbon footprints of motorized transport modes. A bus going from Harrisburg to Florence will emit less CO2 than a car or an airplane.
Make a music playlist for your bus ride from Harrisburg to Florence, and enjoy the scenery to tunes from your own personal soundtrack.
Did you know?
One of the longest bus route in the world goes all the way from Ontario to Alberta in Canada (with the same bus). This trip is 3,435 km or 2,135 miles long and the price is a bit under $100.
The word 'bus' is an abbreviation of 'omnibus" which means 'for all' in Latin as buses were meant to be transportation for everybody.
Did you know there are on average 4,400 intercity bus departures every day in the US only? This number has been growing for 9 years in a row, yay!
What's the cheapest way to go from Harrisburg to Florence, SC, US?
The bus is the cheapest travel choice for this destinationTop traveled bus routes
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