What is the distance between Harrisburg and Florence?

Harrisburg and Florence are 446 miles (718 km) apart.

What are the departure and arrival stations when taking the bus from Harrisburg to Florence?

If you're headed to Florence from Harrisburg, chances are that your bus will depart from Harrisburg Bieber Greyhound Station and arrive at Florence Bus Station. These are the main departure and arrival locations on this route, but you could find others that could be a better fit for your travel plans.

What are the best sights and things to do in Florence?

Once in Florence, you can start exploring the city and discover its surroundings. The top sights and things to do are Villa Gamberaia, Basilica di San Lorenzo, Basilica Santa Croce, Museo degli Innocenti and Galleria degli Uffizi.

Bus Harrisburg to Florence from $77 | Refundable Tickets

Next departures

Next departures for Harrisburg to Florence on November 3
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended	Price and booking link
FlixBus + Greyhound Lines, Inc.		2:40pm	Harrisburg Bus Station	21h 35m	12:15pm	Bus station	CheapestFastest

Last refresh of the prices: 10/26/2025 EDT.

Compare 2 ways to go from Harrisburg to Florence

We recommend taking the train

Among the sustainable travel choices, the train stands out as the good way to reach Florence. The journey takes about 14 hours 5 minutes and with fares starting at just $172, it presents an excellent value for a comfortable ride.

1train per day

14h 5mAverage Duration

447 milesDistance

66kgCO₂ emissions

	Average Price	Average Duration	CO₂ emissions
Bus	Average Price$77 - $234	Average Duration22h 5m	CO₂ emissions 18kg CO₂e
Train	Average Price$172 - $343	Average Duration14h 5m	CO₂ emissions 66kg CO₂e

Bus Harrisburg to Florence, SC, US: Trip Overview

Average ticket price$150

Average bus trip duration22h 5m

Number of daily buses2

Earliest bus departure12:25pm

Distance448 miles (721 km)

Latest bus departure11:20pm

Compare bus companies

FlixBus

3.5/511,161 reviews

Staff4.1

Timeliness3.9

Cleanliness4.1

Wifi2.7

Flixbus is a European bus operator that offers intercity and bus travel in over 38 countries. Known for their easy-to-spot lime green buses and for offering affordable transportation between cities in Europe and the Americas, Flixbus is a good option for those looking for an affordable, reliable bus company. In their buses, you'll find free WiFi, bathrooms, and power outlets. You can also pay extra to choose your seat and get extra legroom, or even buy a snack or drink onboard directly from the driver. You can reschedule your ticket for a small fee, which varies from $1 to $5, depending on how close you are to the departure date.

Greyhound

3.5/587,348 reviews

Staff3.6

Timeliness2.9

Cleanliness3.3

Wifi2.4

Greyhound Lines offers the most comprehensive intercity bus services in the United States. They operate a modern, environmentally friendly fleet that serves more than 2400 destinations and carries nearly 16 million passengers annually. When traveling with them, you can expect free WiFi, onboard entertainment, bathrooms, power outlets and decent legroom. One of the great perks of Greyhound is that they connect big cities and smaller towns in the US, where you usually can't get to by train or plane. If you're looking for safe and affordable transportation, Greyhound is a great choice.

US bus companies: FlixBus, BlaBlaCar Bus, ALSA, Greyhound, Intercape, Trenitalia, Sindbad

Harrisburg to Florence Bus

With Busbud, comparing and booking tickets for a bus from Harrisburg to Florence is a breeze. Browse through an extensive selection of bus fares and bus schedules to find the best deals.

Bus service from Harrisburg to Florence will be provided by the most trusted bus companies.

Discover how much the bus trip from Harrisburg to Florence will cost you. Use our filters and sorting features to find the cheapest bus tickets or luxury buses.

Where are the popular stops in Harrisburg and Florence?

Stops in Harrisburg

A - Harrisburg Bieber Greyhound Station

Stops in Florence

A - Florence Bus Station

B - TA Travel Center - Florence

Frequently asked questions for your trip Harrisburg - Florence, SC, US

What is the distance between Harrisburg and Florence?
What are the departure and arrival stations when taking the bus from Harrisburg to Florence?
What are the best sights and things to do in Florence?

About Bus Travel

Bus Travel Tips

Meet and talk to locals at the bus stations while traveling from Harrisburg to Florence.There is no better way to get inside travel information while exploring a new city than to go straight to its people.

Much more than a mere vehicle taking you from Harrisburg to Florence, riding the bus will expose you to some of the most stunning panoramas while enroute to your final bus stop.

Buses have one of the smallest carbon footprints of motorized transport modes. A bus going from Harrisburg to Florence will emit less CO2 than a car or an airplane.

Make a music playlist for your bus ride from Harrisburg to Florence, and enjoy the scenery to tunes from your own personal soundtrack.

Did you know?

One of the longest bus route in the world goes all the way from Ontario to Alberta in Canada (with the same bus). This trip is 3,435 km or 2,135 miles long and the price is a bit under $100.

The word 'bus' is an abbreviation of 'omnibus" which means 'for all' in Latin as buses were meant to be transportation for everybody.

Did you know there are on average 4,400 intercity bus departures every day in the US only? This number has been growing for 9 years in a row, yay!

What's the cheapest way to go from Harrisburg to Florence, SC, US?

The bus is the cheapest travel choice for this destination

Vehicle Type	Travel Time	Avg Price	Daily Departures
Vehicle TypeBus	Travel Time22h 5m	Avg Price$150	Daily Departures2
Vehicle TypeTrain	Travel Time14h 5m	Avg Price$196	Daily Departures1

Will you be returning to Harrisburg by bus?

Bus from Florence, SC, US to Harrisburg

You can also go to Florence, SC, US by train

Train from Harrisburg to Florence, SC, US

Top traveled bus routes

Why choose Busbud?

The Best Way To Book Bus and Train Tickets

Busbud makes bus travel easy. We help travelers find a bus, plot routes, and book intercity bus tickets all over the world. With several language and currency options available, Busbud seeks to cater to international bus travelers no matter where they are in the world. With Busbud, you can buy tickets with confidence. We ensure that you make the most out of your bus trip by partnering up with reliable bus companies from all around the world such as Greyhound, Eurolines, ALSA, OUIBUS (BlaBlaBus), National Express and many others.

Bus Tickets from Harrisburg to Florence, SC, US

Next departures

Compare 2 ways to go from Harrisburg to Florence

Bus Harrisburg to Florence, SC, US: Trip Overview

Compare bus companies

Harrisburg to Florence Bus

Where are the popular stops in Harrisburg and Florence?

Frequently asked questions for your trip Harrisburg - Florence, SC, US

What is the distance between Harrisburg and Florence?

What are the departure and arrival stations when taking the bus from Harrisburg to Florence?

What are the best sights and things to do in Florence?

About Bus Travel

Bus Travel Tips

Did you know?

What's the cheapest way to go from Harrisburg to Florence, SC, US?

Will you be returning to Harrisburg by bus?

You can also go to Florence, SC, US by train

Top traveled bus routes

Why choose Busbud?

The Best Way To Book Bus and Train Tickets

People from around the world trust Busbud

Popular Buses Connecting Harrisburg

Buses Leaving from Harrisburg

Buses Going to Harrisburg

Popular Buses Connecting Florence

Buses Leaving from Florence

Buses Going to Florence

Popular routes in this country

Popular airport transfers