Find coaches from San Luis, AR to Santiago, CL

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Today14 Jun
Tomorrow15 Jun
Mon16 Jun
Tue17 Jun
Wed18 Jun
from US$61
Thu19 Jun
Fri20 Jun
Sat21 Jun

Cheap buses leaving Wednesday

One passenger / one way

  • This trip is recommended because it is the: Cheapest
    Departure time: 18 June at
    Departure city: San Luis
    Departure location: Ediro San Luis
    Arrival time: 18 June at
    Destination city: Santiago
    Destination location: Santiago De Chile
    Operated by: Tu EnvidiaTu Envidia
    Vehicle: BusDuration:
  • This trip is recommended because it is the: Fastest
    Departure time: 18 June at
    Departure city: San Luis
    Departure location: Ediro San Luis
    Arrival time: 18 June at
    Destination city: Santiago
    Destination location: Santiago De Chile
    Operated by: Tu EnvidiaTu Envidia
    Vehicle: BusDuration:
  • Departure time: 18 June at
    Departure city: San Luis
    Departure location: Ediro San Luis
    Arrival time: 18 June at
    Destination city: Santiago
    Destination location: Santiago De Chile
    Operated by: Tu EnvidiaTu Envidia
    Vehicle: BusDuration:

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Bus San Luis to Santiago: Trip Overview

Average ticket priceUS$88
Average bus trip duration12h 10m
Number of daily buses1
Earliest bus departure11:20
Distance253 miles

San Luis to Santiago Bus

Busbud helps you find a bus from San Luis to Santiago. Get the best fare and schedule, book a round trip ticket or find buses with WiFi and electrical outlets.

We make sure you can find a bus service from San Luis to Santiago from the most reliable bus companies operating this trip.

Whether it is cheap bus tickets or more luxurious buses going to Santiago from San Luis, we help you find what you're looking for based on how much of a budget you have.

Frequently asked questions on the trip San Luis, AR - Santiago, CL

  1. How much does a coach ticket from San Luis to Santiago cost?

    The prices typically range from US$88 to US$88 on this trip, with the average ticket costing US$88. The actual price may differ based on factors like the time you plan to travel, the day of the week, and the coach service provider you select. To get accurate and up-to-date pricing information, check out all your options on our search tool.

  2. How long does the coach from San Luis to Santiago take?

    The coach journey between San Luis and Santiago lasts about 12h 10m. The fastest coach journey typically takes 12h 10m. However, please keep in mind that your specific travel time may vary due to the prevailing traffic conditions along the route.

  3. At what time does the first coach from San Luis to Santiago leave?

    The first coach to Santiago from San Luis departs at 11:20. Keep in mind that departure times might change on weekends and holidays.

  4. What's the distance between San Luis and Santiago by coach?

    The journey from San Luis to Santiago by coach covers an approximate distance of 245 miles (394 km).

  5. How can I get from San Luis to Santiago without driving?

    The best way to go from San Luis to Santiago without a car is by coach. They are frequent and reliable, offering a convenient and eco-friendly journey. Depending on your preferences, carpooling can also be considered as an option.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
12/06
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Today
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18/06
US$57
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busbud logoThe cheapest trip from San Luis to Santiago was searched and found on 18 Jun 2025 with a price of US$57

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from San Luis to Santiago as early as possible.

You can expect to pay from US$57 to US$69 for a bus ticket from San Luis to Santiago based on the last 2 days. You can expect to find the cheapest price for the trip at US$57, which is on 2025-06-18.

About Bus Travel

Bus Travel Tips

Make friends with the driver. They usually know a lot about your destination and may even recommend which side of the bus to sit on to get the best views on the road between San Luis and Santiago!

Start sightseeing the minute your bus leaves the station. If you're on the night bus from San Luis to Santiago, get comfy and count the stars.

Buses are energy-efficient. Carrying a passenger over 100 kms by coach only takes 0.6-0.9 liters of gas. Compare that to the 2.6 liters required by high-speed train, 6.6 liters by airplane and 7.6 liters by gas-powered car, and it's clear that the bus is a more environmentally-conscious option for your bus transportation from San Luis to Santiago.

Create your own real life musical score by curating a personalized bus travel playlist - the perfect accompaniment to your bus ride from San Luis to Santiago.

Did you know?

It takes 27 hours to go by bus from Lima to Cusco, one of the craziest bus trips on the world. This route is used daily by locals and backpackers.

Did you know there are on average 4,400 intercity bus departures every day in the US only? This number has been growing for 9 years in a row, yay!

The word 'bus' is an abbreviation of 'omnibus" which means 'for all' in Latin as buses were meant to be transportation for everybody.

Will you be returning to San Luis by bus?

Bus from San Luis to Santiago

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