Find coaches from St. Louis to Harrisburg

Next departures

Next departures from St. Louis to Harrisburg on 31 October
Operated byVehicle typeDeparture timeDeparture locationTrip durationArrival timeArrival locationRecommendedPrice and booking link
Greyhound Lines, Inc.
Gateway Station
Harrisburg Bus StationCheapest
Greyhound Lines, Inc.
Gateway Station
Harrisburg Bus StationFastest
Greyhound Lines, Inc.
Gateway Station
Harrisburg Bus StationNo tags
FlixBus + Greyhound Lines, Inc.
Gateway Station
Harrisburg Bus StationNo tags

Last refresh of the prices: Yesterday at 12:23 PM CDT.

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Compare 2 ways to travel from St. Louis to Harrisburg

busbud logoWe recommend taking the bus

Among the sustainable travel choices, the bus stands out as a good way to reach Harrisburg. The journey takes about 19 hours 45 minutes and with fares starting at just US$84, it presents an excellent value for a comfortable ride.

3bus per day
19h 45mAverage duration
1158 kmDistance
29kgCO₂ emissions
Bus
Average priceUS$84 - US$183Average duration19h 45m
29kg CO₂e
Train
Average priceUS$182 - US$775Average duration1d 3h
105kg CO₂e

Bus St. Louis to Harrisburg: Trip Overview

Average ticket priceUS$111
Average bus trip duration19h 45m
Number of daily buses3
Earliest bus departure02:00
Distance1157 km
Latest bus departure23:30

St. Louis to Harrisburg Bus

Busbud helps you find a bus from St. Louis to Harrisburg. Get the best fare and schedule, book a round trip ticket or find buses with WiFi and electrical outlets.

Bus service from St. Louis to Harrisburg will be provided by the most trusted bus companies.

From cheap bus tickets to more luxurious buses travelling from St. Louis to Harrisburg, we offer a wide range of bus services to best suit your needs depending on how much your budget is.

Frequently asked questions on the trip St. Louis - Harrisburg

  1. How much does a bus ticket from St. Louis to Harrisburg cost?

    The bus ticket price from St. Louis to Harrisburg starts at US$84. The best way to find cheap bus tickets from St. Louis to Harrisburg is to book your tickets as early as possible. Prices tend to rise as your travel date approaches, so book in advance to secure the best prices!

  2. How long is the bus ride from St. Louis to Harrisburg?

    The average travel time between St. Louis and Harrisburg is around 19h 45m, although the fastest bus will take about 19h 20m. This is the time it takes to travel the 1158 km that separates the two cities.

  3. How many daily bus connections are there between St. Louis and Harrisburg?

    The number of buses from St. Louis to Harrisburg can differ depending on the day of the week. On average, there are 3 on this route. Some buses run direct routes, while others have layovers. Simplify your bus trip from St. Louis to Harrisburg by comparing and selecting the bus that fits your travel style and budget on Busbud.

  4. Which bus companies travel from St. Louis to Harrisburg?

    When taking the bus from St. Louis to Harrisburg, you can travel comfortably and safely with Greyhound, FlixBus.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
28/10
US$103
29/10
US$103
Today
US$106
31/10
US$103
01/11
No data
02/11
No data
03/11
No data
04/11
No data
busbud logoThe cheapest trip from St. Louis to Harrisburg was searched and found on 28 Oct 2025 with a price of US$103

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from St. Louis to Harrisburg as early as possible.

You can expect to pay from US$103 to US$152 for a bus ticket from St. Louis to Harrisburg based on the last 2 days. You can expect to find the cheapest price for the trip at US$103, which is on 2025-10-31.

About Bus Travel

Bus Travel Tips

Make friends with the driver. They usually know a lot about your destination and may even recommend which side of the bus to sit on to get the best views on the road between St. Louis and Harrisburg!

Much more than a mere vehicle taking you from St. Louis to Harrisburg, riding the bus will expose you to some of the most stunning panoramas while enroute to your final bus stop.

Taking the bus creates the smallest carbon footprint compared to other modes of transport. Not to mention that buses will allow you to discover scenic gems from St. Louis to Harrisburg that are otherwise impossible to come by with a plane.

Tune out to the fine sounds of your best music playlist on your bus trip from St. Louis to Harrisburg while indulging in miles on end of beautiful scenic views.

Did you know?

It takes 27 hours to go by bus from Lima to Cusco, one of the craziest bus trips on the world. This route is used daily by locals and backpackers.

9.2% of ground transportation in Europe is done by bus versus 7.4% by train.

The Superbus, created by a Dutch engineer is the world's fastest bus with 250 km/h. Too bad it's only a prototype for now.

What's the cheapest way to go from St. Louis to Harrisburg?

busbud logoThe bus is the cheapest travel choice for this destination

Will you be returning to St. Louis by bus?

Bus from Harrisburg to St. Louis

You can also go to Harrisburg by train

Train from St. Louis to Harrisburg

Why choose Busbud?

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Busbud helps you easily search, compare and book intercity bus tickets on a worlwide scale with our comprehensive list of bus routes and schedules. With Busbud, wherever you go, you have a worldwide bus station within reach and available in your own language and currency. Busbud partners with safe and reliable bus companies throughout the world such as Greyhound, Eurolines, ALSA, OUIBUS (BlaBlaBus), National Express and many others so you can buy tickets without a worry.

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