Bus Tickets from St. Louis to Harrisburg

Next departures

Next departures for St. Louis to Harrisburg on October 11
Operated byVehicle typeDeparture timeDeparture locationTrip durationArrival timeArrival locationRecommendedPrice and booking link
FlixBus + Greyhound Lines, Inc.
Gateway Station
Harrisburg Bus StationCheapestFastest

Last refresh of the prices: Yesterday at 9:45 AM CDT.

Accepted payments

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Compare 2 ways to go from St. Louis to Harrisburg.

Bus
Average Price$81 - $144Average Duration20h 5m
29kg CO₂e5 out of 5 stars
CheapestFastestMost eco-friendly
Train
Average Price$182 - $324Average Duration1d 3h
105kg CO₂e1 out of 5 stars
busbud logoBusbud recommends taking the bus from St. Louis to Harrisburg

Among the sustainable travel choices, the bus stands out as the good way to reach Harrisburg. The journey takes about 20 hours 5 minutes and with fares starting at just $81, it presents an excellent value for a comfortable ride.

5bus per day
20h 5mAverage Duration
$81Cheapest ticket
29kgCO₂ emissions

Bus St. Louis to Harrisburg: Trip Overview

Average ticket price$104
Average bus trip duration20h 5m
Number of daily buses5
Earliest bus departure2:00am
Distance718 miles (1157 km)
Latest bus departure11:30pm

St. Louis to Harrisburg Bus

Busbud helps you find a bus from St. Louis to Harrisburg. Get the best fare and schedule, book a round trip ticket or find buses with WiFi and electrical outlets.

Bus service from St. Louis to Harrisburg will be provided by the most trusted bus companies.

From cheap bus tickets to more luxurious buses traveling from St. Louis to Harrisburg, we offer a wide range of bus services to best suit your needs depending on how much your budget is.

Frequently asked questions for your trip St. Louis - Harrisburg

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
10/09
No data
10/10
No data
Today
$112
10/12
No data
10/13
$91
10/14
No data
10/15
No data
10/16
No data
busbud logoThe cheapest trip from St. Louis to Harrisburg was searched and found on Oct 13, 2025 with a price of $91

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from St. Louis to Harrisburg, as early as possible.

You can expect to pay from $91 to $127 for a bus ticket from St. Louis to Harrisburg based on the last 2 days. You can expect to find the cheapest price for the trip at $91 which is on 2025-10-13.

About Bus Travel

Bus Travel Tips

Make friends with the driver. They usually know a lot about your destination and may even recommend which side of the bus to sit on to get the best views on the road between St. Louis and Harrisburg!

Much more than a mere vehicle taking you from St. Louis to Harrisburg, riding the bus will expose you to some of the most stunning panoramas while enroute to your final bus stop.

Taking the bus creates the smallest carbon footprint compared to other modes of transport. Not to mention that buses will allow you to discover scenic gems from St. Louis to Harrisburg that are otherwise impossible to come by with a plane.

Tune out to the fine sounds of your best music playlist on your bus trip from St. Louis to Harrisburg while indulging in miles on end of beautiful scenic views.

Did you know?

It takes 27 hours to go by bus from Lima to Cusco, one of the craziest bus trips on the world. This route is used daily by locals and backpackers.

9.2% of ground transportation in Europe is done by bus versus 7.4% by train.

The Superbus, created by a Dutch engineer is the world's fastest bus with 250 km/h. Too bad it's only a prototype for now.

What's the cheapest way to go from St. Louis to Harrisburg?

busbud logoThe bus is the cheapest travel choice for this destination

Will you be returning to St. Louis by bus?

Bus from Harrisburg to St. Louis

You can also go to Harrisburg by train

Train from St. Louis to Harrisburg

Why choose Busbud?

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