- Buffalo to Des Moines buses
Previously seen trips
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
FlixBus + Greyhound | Bus | Niagara Frontier Transportation Authority | Des Moines (Subway) | No tags | ||||
Greyhound + FlixBus | Bus | Buffalo (BUF) Airport | Des Moines (Subway) | No tags | ||||
![]() | Bus | Niagara Frontier Transportation Authority | Des Moines (Subway) | No tags |
Get from Buffalo to Des Moines
The journey takes about 1 day, 7 hours 40 minutes and with fares starting at just $176, it presents an excellent value for a comfortable ride.
Where are the popular stops in Buffalo and Des Moines?
Stops in Buffalo
- B185 Ellicott St, Buffalo, NY 14203, USA
- C75 Exchange St, Buffalo, NY 14203, USA
Stops in Des Moines
- A
Jefferson/Trailways Depot
1501 2nd Ave North, Des Moines, IA 50314 - B
1514 East Grand Ave
1514 East Grand Avenue,, Des Moins, IA, 50316
Compare bus companies
Greyhound Lines offers the most comprehensive intercity bus services in the United States. They operate a modern, environmentally friendly fleet that serves more than 2400 destinations and carries nearly 16 million passengers annually. When traveling with them, you can expect free WiFi, onboard entertainment, bathrooms, power outlets and decent legroom. One of the great perks of Greyhound is that they connect big cities and smaller towns in the US, where you usually can't get to by train or plane. If you're looking for safe and affordable transportation, Greyhound is a great choice.
Frequently asked questions about traveling from Buffalo, NY to Des Moines by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from Buffalo to Des Moines?
The cheapest bus tickets from Buffalo to Des Moines start from $176. The average price for this route is around $176. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Buffalo to Des Moines?
The average bus trip duration from Buffalo to Des Moines is 1d 7h, covering a distance of 756 miles (1220 km). The quickest bus can get you there in 1d 7h and is operated by Greyhound.
Which bus companies service the Buffalo to Des Moines route?
Several major train operators operate on this route with 1 trains available per day.
What is the earliest and latest departure time for the bus from Buffalo to Des Moines?
The earliest bus departs from Buffalo to Des Moines at 7:55am. And the latest bus departs at 11:20pm.
What are the CO₂ emissions for the bus trip from Buffalo to Des Moines?
A bus trip from Buffalo to Des Moines generates an estimated 30 kg of CO₂, making it a highly eco-friendly travel option and recommended mode of travel by Busbud.






