Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
FlixBus + Greyhound Lines, Inc. | Bus | Chicago 95Th & Dan Ryan | GK Butterfield Transportation Center | Cheapest | ||||
 | Bus | Downtown Greyhound Station | GK Butterfield Transportation Center | Fastest | ||||
| Bus | Downtown Greyhound Station | GK Butterfield Transportation Center | No tags | ||||
Greyhound Lines, Inc. + FlixBus | Bus | 537-517 W. Jackson Blvd | GK Butterfield Transportation Center | No tags | ||||
| Bus | 537-517 W. Jackson Blvd | GK Butterfield Transportation Center | No tags |
Last refresh of the prices: Today at 10:23 PM CST.
Get from Chicago to Greenville
The journey takes about 1 day, 5 hours 45 minutes and with fares starting at just $167, it presents an excellent value for a comfortable ride.
Compare bus companies
Frequently asked questions about traveling from Chicago to Greenville, NC by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from Chicago to Greenville?
The cheapest bus tickets from Chicago to Greenville start from $167. The average price for this route is around $195. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Chicago to Greenville?
The average bus trip duration from Chicago to Greenville is 1d 5h, covering a distance of 694 miles (1119 km). The quickest bus can get you there in 1d 5h and is operated by Greyhound.
Which bus companies service the Chicago to Greenville route?
What is the earliest and latest departure time for the bus from Chicago to Greenville?
The earliest bus departs from Chicago to Greenville at 5:45am. And the latest bus departs at 10:30pm.
What are the CO₂ emissions for the bus trip from Chicago to Greenville?
A bus trip from Chicago to Greenville generates an estimated 28 kg of CO₂, making it a highly eco-friendly travel option and recommended mode of travel by Busbud.
What is the best bus company from Chicago to Greenville?
According to Busbud customers, the highest-rated bus company on this route is Greyhound, with an average rating of 3.5 out of 5 stars based on 87463 reviews.
Which bus company has the best Wi-Fi from Chicago to Greenville?
Based on reviews on Busbud, the bus company FlixBus has the best Wi-Fi rating with a score of 2.7.
Which bus company has the most timely service from Chicago to Greenville?
According to Busbud traveller reviews, the most timely bus company on this route is FlixBus, with a punctuality rating of 3.9 out of 5 stars.
Which bus company has the cleanest buses from Chicago to Greenville?
According to Busbud traveller reviews, the bus company with the cleanest buses on this route is FlixBus, with a cleanliness rating of 4.1 out of 5 stars.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Chicago to Greenville, NC was searched and found on Jan 12, 2026 with a price of $167To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Chicago to Greenville, NC, as early as possible.
You can expect to pay from $167 to $217 for a bus ticket from Chicago to Greenville, NC based on the last 2 days. You can expect to find the cheapest price for the trip at $167 which is on 2026-01-12.
