Bus Tickets from Chicago to Greenville, NC

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Previously seen trips

One passenger / one way

  • Departure time: November 12 at
    Departure city: Chicago
    Departure location: Downtown Greyhound Station
    Arrival time: November 13 at
    Destination city: Greenville
    Destination location: GK Butterfield Transportation Center
    Operated by: GreyhoundGreyhound
    Vehicle: BusDuration:
  • Departure time: November 12 at
    Departure city: Chicago
    Departure location: Chicago 95Th & Dan Ryan
    Arrival time: November 14 at
    Destination city: Greenville
    Destination location: GK Butterfield Transportation Center
    Operated by: Greyhound + FlixBus
    Greyhound + FlixBus
    Vehicle: BusDuration:
  • Departure time: November 12 at
    Departure city: Chicago
    Departure location: Downtown Greyhound Station
    Arrival time: November 14 at
    Destination city: Greenville
    Destination location: GK Butterfield Transportation Center
    Operated by: GreyhoundGreyhound
    Vehicle: BusDuration:
  • Departure time: March 8 at
    Departure city: Chicago
    Departure location: 537-517 W. Jackson Blvd
    Arrival time: March 10 at
    Destination city: Greenville
    Destination location: GK Butterfield Transportation Center
    Operated by: GreyhoundGreyhound
    Vehicle: BusDuration:
  • Departure time: March 10 at
    Departure city: Chicago
    Departure location: Downtown Greyhound Station
    Arrival time: March 11 at
    Destination city: Greenville
    Destination location: GK Butterfield Transportation Center
    Operated by: GreyhoundGreyhound
    Vehicle: BusDuration:

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Compare 2 ways to go from Chicago to Greenville.

Bus
Average Price$141 - $201Average Duration1d 11h
28kg CO₂e5 out of 5 stars
CheapestFastestMost eco-friendly
Train
Average Price$275 - $342Average Duration1d 20h
103kg CO₂e1 out of 5 stars
busbud logoBusbud recommends taking the bus from Chicago to Greenville

Among the sustainable travel choices, the bus stands out as the good way to reach Greenville. The journey takes about 1 day, 11 hours 31 minutes and with fares starting at just $141, it presents an excellent value for a comfortable ride.

5bus per day
1d 11hAverage Duration
$141Cheapest ticket
28kgCO₂ emissions

Bus Chicago to Greenville, NC: Trip Overview

Average ticket price$170
Average bus trip duration1d 11h
Number of daily buses5
Earliest bus departure12:40am
Distance700 miles (1129 km)
Latest bus departure11:59pm

Chicago to Greenville Bus

Busbud helps you find a bus from Chicago to Greenville. Get the best fare and schedule, book a round trip ticket or find buses with WiFi and electrical outlets.

We make sure you can find a bus service from Chicago to Greenville from the most reliable bus companies operating this trip.

Whether it is cheap bus tickets or more luxurious buses going to Greenville from Chicago, we help you find what you're looking for based on how much of a budget you have.

Frequently asked questions for your trip Chicago - Greenville, NC

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
09/03
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Today
$140
09/06
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busbud logoThe cheapest trip from Chicago to Greenville, NC was searched and found on Sep 5, 2025 with a price of $140

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Chicago to Greenville, NC, as early as possible.

About Bus Travel

Bus Travel Tips

Make friends with the driver. They usually know a lot about your destination and may even recommend which side of the bus to sit on to get the best views on the road between Chicago and Greenville!

Start sightseeing the minute your bus leaves the station. If you're on the night bus from Chicago to Greenville, get comfy and count the stars.

Buses are energy-efficient. Carrying a passenger over 100 kms by coach only takes 0.6-0.9 liters of gas. Compare that to the 2.6 liters required by high-speed train, 6.6 liters by airplane and 7.6 liters by gas-powered car, and it's clear that the bus is a more environmentally-conscious option for your bus transportation from Chicago to Greenville.

Create your own real life musical score by curating a personalized bus travel playlist - the perfect accompaniment to your bus ride from Chicago to Greenville.

Did you know?

It takes 27 hours to go by bus from Lima to Cusco, one of the craziest bus trips on the world. This route is used daily by locals and backpackers.

Did you know there are on average 4,400 intercity bus departures every day in the US only? This number has been growing for 9 years in a row, yay!

The average number of passengers on a coach bus is 32 meaning that a bus could replace a minimum of at least 30 cars!

What's the cheapest way to go from Chicago to Greenville, NC?

busbud logoThe bus is the cheapest travel choice for this destination

Will you be returning to Chicago by bus?

Bus from Greenville, NC to Chicago

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