Previously seen trips
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Bus station | Niagara Frontier Transportation Authority | No tags | ||||
Greyhound + FlixBus | Bus | Bus station | Buffalo (BUF) Airport | No tags | ||||
 | Bus | Florence, SC | Niagara Frontier Transportation Authority | No tags | ||||
| Bus | Florence, SC | Buffalo (BUF) Airport | No tags | ||||
| Bus | Bus station | Niagara Frontier Transportation Authority | No tags |
Compare 2 ways to go from Florence to Buffalo
Among the sustainable travel choices, the bus stands out as a good way to reach Buffalo. The journey takes about 1 day, 1 hour, and with fares starting at just $168, it presents an excellent value for a comfortable ride.
Where are the popular stops in Florence and Buffalo?
Stops in Florence
- A619 S Irby St, Florence, SC 29501, USA
- B
TA Travel Center - Florence
2301 W Lucas St, Florence, SC 29501, USA
Stops in Buffalo
- B185 Ellicott St, Buffalo, NY 14203, USA
- C75 Exchange St, Buffalo, NY 14203, USA
Compare bus companies
Frequently asked questions about travelling from Florence, SC, US to Buffalo, NY by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from Florence to Buffalo?
The cheapest bus tickets from Florence to Buffalo start from $168. The average price for this route is around $289. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Florence to Buffalo?
The average bus travel time from Florence to Buffalo is 1d 1h, covering a distance of 976 km. The quickest bus can get you there in 22h 20m and is operated by FlixBus.
Which bus companies service the Florence to Buffalo route?
What are the earliest and latest departure times for the bus from Florence to Buffalo?
The earliest bus departs from Florence to Buffalo at 12:05am. And the latest bus departs at 4:30pm.
What are the CO₂ emissions for the bus trip from Florence to Buffalo?
A bus trip from Florence to Buffalo generates an estimated 24 kg of CO₂, making it a highly eco-friendly travel option and a mode of travel recommended by Busbud.
What is the best bus company from Florence to Buffalo?
According to Busbud customers, the highest-rated bus company on this route is FlixBus, with an average rating of 3.5 out of 5 stars based on 11638 reviews.
Which bus company has the best Wi-Fi from Florence to Buffalo?
Based on Busbud reviews, the bus company FlixBus has the highest Wi-Fi rating with a score of 2.7.
Which bus company has the best on-time performance from Florence to Buffalo?
According to Busbud traveller reviews, the most punctual bus company on this route is FlixBus, with a punctuality rating of 3.9 out of 5 stars.
Which bus company has the cleanest buses from Florence to Buffalo?
According to Busbud traveller reviews, the bus company with the cleanest buses on this route is FlixBus, with a cleanliness rating of 4.1 out of 5 stars.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Florence, SC, US to Buffalo, NY was searched and found on Dec 25, 2025 with a price of $178To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Florence, SC, US to Buffalo, NY, as early as possible.
You can expect to pay from $178 to $241 for a bus ticket from Florence, SC, US to Buffalo, NY based on the last 2 days. You can expect to find the cheapest price for the trip at $178 which is on 2025-12-25.
What's the cheapest way to go from Florence, SC, US to Buffalo, NY?
The bus is the cheapest travel choice for this destination
