Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
FlixBus + Greyhound Lines, Inc. | Bus | Rosa Parks Station | Tupelo (Brothers Quick Stop) | CheapestFastest | ||||
 | Bus | Gainesville Bus Stop | Tupelo (Brothers Quick Stop) | No tags | ||||
FlixBus + Greyhound Lines, Inc. | Bus | Rosa Parks Station | Tupelo (Brothers Quick Stop) | No tags |
Last refresh of the prices: Today at 12:23 AM EST.
Get from Gainesville to Tupelo
The journey takes about 14 hours 5 minutes and with fares starting at just $133, it presents an excellent value for a comfortable ride.
Compare bus companies
Greyhound Lines offers the most comprehensive intercity bus services in the United States. They operate a modern, environmentally friendly fleet that serves more than 2400 destinations and carries nearly 16 million passengers annually. When traveling with them, you can expect free WiFi, onboard entertainment, bathrooms, power outlets and decent legroom. One of the great perks of Greyhound is that they connect big cities and smaller towns in the US, where you usually can't get to by train or plane. If you're looking for safe and affordable transportation, Greyhound is a great choice.
Frequently asked questions about traveling from Gainesville, FL to Tupelo by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from Gainesville to Tupelo?
The cheapest bus tickets from Gainesville to Tupelo start from $133. The average price for this route is around $137. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Gainesville to Tupelo?
The average bus trip duration from Gainesville to Tupelo is 14h 5m, covering a distance of 489 miles (788 km). The quickest bus can get you there in 14h 5m and is operated by Greyhound.
Which bus companies service the Gainesville to Tupelo route?
Several major bus companies operate on this route with 3 buses available per day.
What is the earliest and latest departure time for the bus from Gainesville to Tupelo?
The earliest bus departs from Gainesville to Tupelo at 1:10am. And the latest bus departs at 9:20pm.
What are the CO₂ emissions for the bus trip from Gainesville to Tupelo?
A bus trip from Gainesville to Tupelo generates an estimated 20 kg of CO₂, making it a highly eco-friendly travel option and recommended mode of travel by Busbud.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Gainesville, FL to Tupelo was searched and found on Feb 1, 2026 with a price of $173To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Gainesville, FL to Tupelo, as early as possible.
You can expect to pay from $173 to $173 for a bus ticket from Gainesville, FL to Tupelo based on the last 2 days. You can expect to find the cheapest price for the trip at $173 which is on 2026-02-01.
