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One passenger / one way
- This trip is recommended because it is: Cheapest + FastestDeparture time: July 27 atDeparture city: Panama CityDeparture location: Panama City Beach StationArrival time: July 28 atDestination city: Big Pine KeyDestination location: Big Pine Key, FLOperated by: Greyhound Lines, Inc.
Vehicle: BusDuration:
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Bus Panama City, US to Big Pine Key: Trip Overview
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Greyhound Lines offers the most comprehensive intercity bus services in the United States. They operate a modern, environmentally friendly fleet that serves more than 2400 destinations and carries nearly 16 million passengers annually. When traveling with them, you can expect free WiFi, onboard entertainment, bathrooms, power outlets and decent legroom. One of the great perks of Greyhound is that they connect big cities and smaller towns in the US, where you usually can't get to by train or plane. If you're looking for safe and affordable transportation, Greyhound is a great choice.
Panama City to Big Pine Key Bus
Busbud helps you find a bus from Panama City to Big Pine Key. Get the best fare and schedule, book a round trip ticket or find buses with WiFi and electrical outlets.
We make sure you can find a bus service from Panama City to Big Pine Key from the most reliable bus companies operating this trip.
Whether it is cheap bus tickets or more luxurious buses going to Big Pine Key from Panama City, we help you find what you're looking for based on how much of a budget you have.
Frequently asked questions for your trip Panama City, US - Big Pine Key
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Panama City, US to Big Pine Key was searched and found on Jul 27, 2025 with a price of $123To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Panama City, US to Big Pine Key, as early as possible.
About Bus Travel
Bus Travel Tips
Make friends with the driver. They usually know a lot about your destination and may even recommend which side of the bus to sit on to get the best views on the road between Panama City and Big Pine Key!
Start sightseeing the minute your bus leaves the station. If you're on the night bus from Panama City to Big Pine Key, get comfy and count the stars.
Buses are energy-efficient. Carrying a passenger over 100 kms by coach only takes 0.6-0.9 liters of gas. Compare that to the 2.6 liters required by high-speed train, 6.6 liters by airplane and 7.6 liters by gas-powered car, and it's clear that the bus is a more environmentally-conscious option for your bus transportation from Panama City to Big Pine Key.
Make a music playlist for your bus ride from Panama City to Big Pine Key, and enjoy the scenery to tunes from your own personal soundtrack.
Did you know?
It takes 27 hours to go by bus from Lima to Cusco, one of the craziest bus trips on the world. This route is used daily by locals and backpackers.
Did you know that 80% of the buses in North America are equipped with WiFi and power outlets ? And 60% of bus travelers have used their electronic device on board during 2014.
The word 'bus' is an abbreviation of 'omnibus" which means 'for all' in Latin as buses were meant to be transportation for everybody.
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Busbud makes bus travel easy. We help travelers find a bus, plot routes, and book intercity bus tickets all over the world. With Busbud, wherever you go, you have a worldwide bus station within reach and available in your own language and currency. Busbud partners with safe and reliable bus companies throughout the world such as Greyhound, Eurolines, ALSA, OUIBUS (BlaBlaBus), National Express and many others so you can buy tickets without a worry.
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