Bus Tickets from St. Louis to Durham, NC, US

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Previously seen trips

One passenger / one way

  • Departure time: October 10 at
    Departure city: St. Louis
    Departure location: Gateway Station
    Arrival time: October 11 at
    Destination city: Durham
    Destination location: Durham Greyhound Bus Station
    Operated by: Greyhound + FlixBus
    Greyhound + FlixBus
    Vehicle: BusDuration:
  • Departure time: October 10 at
    Departure city: St. Louis
    Departure location: Gateway Station
    Arrival time: October 11 at
    Destination city: Durham
    Destination location: Durham Greyhound Bus Station
    Operated by: GreyhoundGreyhound
    Vehicle: BusDuration:
  • Departure time: November 16 at
    Departure city: St. Louis
    Departure location: Gateway Station
    Arrival time: November 17 at
    Destination city: Durham
    Destination location: Durham Greyhound Bus Station
    Operated by: Greyhound + FlixBus
    Greyhound + FlixBus
    Vehicle: BusDuration:
  • Departure time: November 16 at
    Departure city: St. Louis
    Departure location: Gateway Station
    Arrival time: November 17 at
    Destination city: Durham
    Destination location: Durham Greyhound Bus Station
    Operated by: GreyhoundGreyhound
    Vehicle: BusDuration:
  • Departure time: December 6 at
    Departure city: St. Louis
    Departure location: Gateway Station
    Arrival time: December 7 at
    Destination city: Durham
    Destination location: Durham Greyhound Bus Station
    Operated by: FlixBus + Greyhound
    FlixBus + Greyhound
    Vehicle: BusDuration:

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Bus St. Louis to Durham, NC, US: Trip Overview

Average ticket price$130
Average bus trip duration23h 25m
Number of daily buses4
Earliest bus departure8:30am
Distance645 miles (1040 km)
Latest bus departure11:30pm

St. Louis to Durham Bus

With Busbud, comparing and booking tickets for a bus from St. Louis to Durham is a breeze. Browse through an extensive selection of bus fares and bus schedules to find the best deals.

We make it our job to connect you with the most dependable bus companies that cover bus service from St. Louis to Durham.

From cheap bus tickets to more luxurious buses traveling from St. Louis to Durham, we offer a wide range of bus services to best suit your needs depending on how much your budget is.

Frequently asked questions for your trip St. Louis - Durham, NC, US

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
08/29
$118
08/30
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Today
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09/01
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busbud logoThe cheapest trip from St. Louis to Durham, NC, US was searched and found on Aug 29, 2025 with a price of $118

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from St. Louis to Durham, NC, US, as early as possible.

About Bus Travel

Bus Travel Tips

Meet and talk to locals at the bus stations while traveling from St. Louis to Durham.There is no better way to get inside travel information while exploring a new city than to go straight to its people.

From miles long of beauteous natural landscapes to impressive man-crafted sights, you're bound to be in for a visual treat on your bus trip from St. Louis to Durham.

Taking the bus creates the smallest carbon footprint compared to other modes of transport. Not to mention that buses will allow you to discover scenic gems from St. Louis to Durham that are otherwise impossible to come by with a plane.

Tune out to the fine sounds of your best music playlist on your bus trip from St. Louis to Durham while indulging in miles on end of beautiful scenic views.

Did you know?

The Superbus, created by a Dutch engineer is the world's fastest bus with 250 km/h. Too bad it's only a prototype for now.

Did you know some bus companies in Germany offer to their passenger low-costs snacks and regional beer based on their destination? Prosit!

The bus driver with the longest career in the world drove more than 2,000,000 miles and is a happy World Record holder.

Will you be returning to St. Louis by bus?

Bus from Durham, NC, US to St. Louis

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