Previously seen trips
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Gateway Station | Greenville Station | No tags | |||||
| Gateway Station | Greenville Station | No tags | |||||
| Gateway Station | Greenville Station | No tags | |||||
| Gateway Station | Greenville Station | No tags | |||||
| Gateway Station | Greenville Station | No tags |
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Compare 2 ways to go from St. Louis to Greenville
Among the sustainable travel choices, the bus stands out as the good way to reach Greenville. The journey takes about 17 hours 40 minutes and with fares starting at just $85, it presents an excellent value for a comfortable ride.
Train St. Louis to Greenville, SC: Trip Overview
Please note, this information is subject to change.
Train Companies
Based on 5559 reviews, the company was rated 4.1 stars on Busbud. Travelers were especially satisfied with the seats and the ticket access but often complained with the wifi. Amtrak ticket prices on this trip start at $246
St. Louis to Greenville Train
With Busbud, comparing and booking tickets for a train from St. Louis to Greenville is a breeze. Browse through an extensive selection of train fares and train schedules to find the best deals.
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Whether it is train tickets or first class train tickets going to Greenville from St. Louis, we help you find what you're looking for based on how much of a budget you have.
Frequently asked questions for your trip St. Louis - Greenville, SC
Find cheapest prices for trains
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from St. Louis to Greenville, SC was searched and found on Oct 30, 2025 with a price of $324To save money and be sure you have the best seat, it's a good idea to buy your train tickets from St. Louis to Greenville, SC, as early as possible.
About Train Travel
Train Travel Tips
Taking the fastest trains allows you to travel at speeds greater than 300 km/h. Taking a trip from St. Louis to Greenville is not only much quicker but more comfortable too! You can usually travel directly to the city centre and save time while you're at it.
Whether you take a regional or high-speed train to Greenville, you’ll help reduce the environmental impact and carbon footprint of your trip. As you watch the landscapes unfold before your eyes, you can tell yourself that with this choice, you are making sure they remain protected.
By choosing the train between St. Louis and Greenville, you emit up to 30 times less CO2 than for the same journey made by plane or car!
Tune out to the fine sounds of your best music playlist on your train trip from St. Louis to Greenville while indulging in miles on end of beautiful scenic views.
Did you know?
You can find the straightest railway in the world in Australia. This railway line is 478 kilometres long and is also considered the longest and straightest railway line in the world.
Railway companies played a major role as early as 1883 in the use of time zones as we know them today.
Some trains in Sweden can recover more than a fifth of the energy they use by braking. This is especially true with ore trains as they descend from Narvik to Kiruna.
Top Traveled Train Routes
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