Compare 2 ways to go from St. Louis to Greenville.
Busbud recommends taking the bus from St. Louis to GreenvilleAmong the sustainable travel choices, the bus stands out as the good way to reach Greenville. The journey takes about 16 hours 45 minutes and with fares starting at just $87, it presents an excellent value for a comfortable ride.
Bus St. Louis to Greenville, SC: Trip Overview
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St. Louis to Greenville Bus
With Busbud, comparing and booking tickets for a bus from St. Louis to Greenville is a breeze. Browse through an extensive selection of bus fares and bus schedules to find the best deals.
We make it our job to connect you with the most dependable bus companies that cover bus service from St. Louis to Greenville.
Whether it is cheap bus tickets or more luxurious buses going to Greenville from St. Louis, we help you find what you're looking for based on how much of a budget you have.
Where are the popular stops in St. Louis and Greenville?
Frequently asked questions for your trip St. Louis - Greenville, SC
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from St. Louis to Greenville, SC was searched and found on Aug 1, 2025 with a price of $103To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from St. Louis to Greenville, SC, as early as possible.
About Bus Travel
Bus Travel Tips
Meet and talk to locals at the bus stations while traveling from St. Louis to Greenville.There is no better way to get inside travel information while exploring a new city than to go straight to its people.
From miles long of beauteous natural landscapes to impressive man-crafted sights, you're bound to be in for a visual treat on your bus trip from St. Louis to Greenville.
Buses are energy-efficient. Carrying a passenger over 100 kms by coach only takes 0.6-0.9 liters of gas. Compare that to the 2.6 liters required by high-speed train, 6.6 liters by airplane and 7.6 liters by gas-powered car, and it's clear that the bus is a more environmentally-conscious option for your bus transportation from St. Louis to Greenville.
Tune out to the fine sounds of your best music playlist on your bus trip from St. Louis to Greenville while indulging in miles on end of beautiful scenic views.
Did you know?
The Superbus, created by a Dutch engineer is the world's fastest bus with 250 km/h. Too bad it's only a prototype for now.
Did you know some bus companies in Germany offer to their passenger low-costs snacks and regional beer based on their destination? Prosit!
The word 'bus' is an abbreviation of 'omnibus" which means 'for all' in Latin as buses were meant to be transportation for everybody.
What's the cheapest way to go from St. Louis to Greenville, SC?
The bus is the cheapest travel choice for this destinationTop traveled bus routes
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Popular Buses Connecting Greenville
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