Bus Tickets from Brussels to Lyon

Find affordable bus tickets from Brussels to Lyon with flexible options. Book your trip now

Join 75M+ travelers booking 2M+ routes across 85+ countries.
Enjoy our 24/7 customer service to assist you at every step.
Cancel anytime and receive a 100% refund, no reason needed.
TodayMay 9
from US$49
TomorrowMay 10
from US$54
SunMay 11
from US$80
MonMay 12
from US$31
TueMay 13
from US$31
WedMay 14
from US$28
ThuMay 15
from US$31
FriMay 16
from US$31

Cheap buses leaving tomorrow

One passenger / one way

  • This trip is recommended because it is the: Cheapest
    Departure time: May 10 at
    Departure city: Brussels
    Departure location: Brussels-South (Gare du Midi)
    Arrival time: May 10 at
    Destination city: Lyon
    Destination location: Lyon - Perrache Bus Station
    Operated by: BlaBlaCar BusBlaBlaCar Bus
    Vehicle: BusDuration:
  • This trip is recommended because it is the: Fastest
    Departure time: May 10 at
    Departure city: Brussels
    Departure location: Brussels-South (Gare du Midi)
    Arrival time: May 10 at
    Destination city: Lyon
    Destination location: Lyon - Perrache Bus Station
    Operated by: BlaBlaCar BusBlaBlaCar Bus
    Vehicle: BusDuration:
  • Departure time: May 10 at
    Departure city: Brussels
    Departure location: Brussels-South (Gare du Midi)
    Arrival time: May 10 at
    Destination city: Lyon
    Destination location: Lyon - Perrache Bus Station
    Operated by: BlaBlaCar BusBlaBlaCar Bus
    Vehicle: BusDuration:
  • Departure time: May 10 at
    Departure city: Brussels
    Departure location: Brussels Airport
    Arrival time: May 10 at
    Destination city: Lyon
    Destination location: Perrache
    Operated by: FlixbusFlixbus
    Vehicle: BusDuration:
  • Departure time: May 10 at
    Departure city: Brussels
    Departure location: Brussels-South (Gare du Midi)
    Arrival time: May 10 at
    Destination city: Lyon
    Destination location: Lyon - Perrache Bus Station
    Operated by: BlaBlaCar BusBlaBlaCar Bus
    Vehicle: BusDuration:

Last refresh of the prices: Today at 4:40 AM CEST.

Prices and availability are subject to change.

Accepted payments

  • Visa
  • MasterCard
  • American Express
  • China Union Pay
  • Diners Club Canada
  • Discover Click to Pay
  • JCB payment
  • Klarna (Pay over time)
  • Google Pay

Compare 3 ways to go from Brussels to Lyon

Bus
Average PriceUS$26 - US$244Average Duration11h 15m
14kg CO₂e5 out of 5 stars
CheapestMost eco-friendly
Train
Average PriceUS$83 - US$362Average Duration4h 13m
14kg CO₂e5 out of 5 stars
Fastest
Carpool
Average PriceUS$39 - US$115Average Duration7h 40m
24kg CO₂e4 out of 5 stars
busbud logoBusbud recommends taking the train from Brussels to Lyon

Among the sustainable travel choices, the train stands out as a good way to reach Lyon. The journey takes about 4 hours 13 minutes, and with fares starting at just US$83, it presents an excellent value for a comfortable ride.

12train per day
4h 13mAverage Duration
US$83Cheapest ticket
14kgCO₂ emissions

Bus Brussels to Lyon: Trip Overview

Average Ticket PriceUS$57
Average Bus Trip Duration11h 15m
Number of daily buses24
Earliest bus departure12:15am
Distance567 km
Latest bus departure10:55pm

Brussels to Lyon Bus

Busbud helps you find a bus from Brussels to Lyon. Get the best fare and schedule, book a round trip ticket or find buses with WiFi and electrical outlets.

We make it our job to connect you with the most dependable bus companies that cover bus service from Brussels to Lyon.

Whether it is cheap bus tickets or more luxurious buses going to Lyon from Brussels, we help you find what you're looking for based on how much of a budget you have.

Frequently asked questions on the trip Brussels - Lyon

  1. How long does it take to get to Lyon from Brussels by bus?

    The trip from Brussels to Lyon will take on average 11h 15m. If you're looking for the fastest way to get there, you'll find a bus doing the trip in about 9h 40m.

  2. What is the distance between Brussels and Lyon?

    It's about 569 km (353 miles) from Brussels to Lyon.

  3. What are the departure and arrival locations for buses traveling from Brussels to Lyon?

    Buses departing from Brux-Nord in Brussels will take you to Perrache in Lyon.

  4. What is the cheapest way to travel from Brussels to Lyon?

    If you're on a budget, consider traveling by bus to Lyon from Brussels; it tends to be more affordable. The ticket price for this bus starts at US$26, making this your best choice for this trip.

  5. How much is the bus from Brussels to Lyon?

    You can expect to pay around US$57 for the bus ride from Brussels to Lyon.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
05-07
US$158
05-08
US$59
Today
US$45
05-10
US$50
05-11
US$75
05-12
US$29
05-13
US$29
05-14
US$26
busbud logoThe cheapest trip from Brussels to Lyon was searched and found on May 14, 2025 with a price of US$26

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Brussels to Lyon, as early as possible.

You can expect to pay from US$26 to US$240 for a bus ticket from Brussels to Lyon based on the last 2 days. You can expect to find the cheapest price for the trip at US$26 which is on 2025-05-14.

Usually Flixbus (BE) will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.

About Bus Travel

Bus Travel Tips

Make friends with the driver. They usually know a lot about your destination and may even recommend which side of the bus to sit on to get the best views on the road between Brussels and Lyon!

From miles long of beauteous natural landscapes to impressive man-crafted sights, you’re bound to be in for a visual treat on your bus trip from Brussels to Lyon.

Buses are energy-efficient. Carrying a passenger over 100 kms by coach only takes 0.6-0.9 liters of gas. Compare that to the 2.6 liters required by high-speed train, 6.6 liters by airplane and 7.6 liters by gas-powered car, and it's clear that the bus is a more environmentally-conscious option for your bus transportation from Brussels to Lyon.

Make a music playlist for your bus ride from Brussels to Lyon, and enjoy the scenery to tunes from your own personal soundtrack.

Did you know?

It takes 27 hours to go by bus from Lima to Cusco, one of the craziest bus trips on the world. This route is used daily by locals and backpackers.

One of the longest bus route in the world goes all the way from Ontario to Alberta in Canada (with the same bus). This trip is 3,435 km or 2,135 miles long and the price is a bit under $100.

The average number of passengers on a coach bus is 32 meaning that a bus could replace a minimum of at least 30 cars!

What's the cheapest way to go from Brussels to Lyon?

busbud logoThe bus is the cheapest travel choice for this destination

Will you be returning to Brussels by bus?

Bus from Brussels to Lyon

You can also go to Lyon by train

Train from Brussels to Lyon

Why choose Busbud?

The Best Way To Book Bus and Train Tickets

Busbud helps you easily search, compare and book intercity bus tickets on a worlwide scale with our comprehensive list of bus routes and schedules. With Busbud, wherever you go, you have a worldwide bus station within reach and available in your own language and currency. Busbud prides itself on its worldwide partnerships. We make it possible for you to buy tickets with its large network of trustworthy bus partners like Greyhound, Eurolines, ALSA, OUIBUS (BlaBlaBus), National Express and many others.

People from around the world trust Busbud

‌

Popular Buses Connecting Brussels

Buses Leaving from Brussels

Buses Going to Brussels

Popular Buses Connecting Lyon

Buses Leaving from Lyon

Buses Going to Lyon