Bus Tickets from Charleston, SC, US to Buffalo, NY

Next bus departures

Next departures for Charleston to Buffalo on November 18
Operated byVehicle typeDeparture timeDeparture locationTrip durationArrival timeArrival locationRecommendedPrice and booking link
Greyhound Lines, Inc. + FlixBus
Bus
4565 Gaynor Ave, North Charleston
Buffalo (BUF) AirportCheapest
Greyhound Lines, Inc.Bus
4565 Gaynor Ave, North Charleston
Niagara Frontier Transportation AuthorityFastest

Last refresh of the prices: Yesterday at 2:34 PM EST.

Compare 2 ways to go from Charleston to Buffalo

We recommend taking the bus

Among the sustainable travel choices, the bus stands out as a good way to reach Buffalo. The journey takes about 1 day, 5 hours 55 minutes, and with fares starting at just $181, it presents an excellent value for a comfortable ride.

2bus per day
1d 5hAverage Duration
1124 kmDistance
28kgCO₂ emissions
Bus
Average Price$181 - $351Average Duration1d 5h
28kg CO₂e
Train
Average Price$306 - $2,468Average Duration1d
102kg CO₂e

Frequently asked questions about travelling from Charleston, SC, US to Buffalo, NY by bus

  1. What is the travel distance from Charleston to Buffalo?

    The distance between Charleston and Buffalo is around 1129 km (700 miles).

  2. What are the departure and arrival locations for buses traveling from Charleston to Buffalo?

    Buses traveling this route start their trip at Charleston Bus Station, in Charleston, and end it at Buffalo Airport, in Buffalo.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

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$218
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busbud logoThe cheapest trip from Charleston, SC, US to Buffalo, NY was searched and found on Nov 18, 2025 with a price of $218

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Charleston, SC, US to Buffalo, NY, as early as possible.

What's the cheapest way to go from Charleston, SC, US to Buffalo, NY?

busbud logoThe bus is the cheapest travel choice for this destination

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