Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Des Moines | Airways Transit Center | CheapestFastest | ||||
Greyhound Lines, Inc. + FlixBus | Bus | Des Moines | Memphis Bus Station | No tags | ||||
 | Bus | Des Moines | Memphis Bus Station | No tags |
Last refresh of the prices: Today at 1:54 PM CST.
Get from Des Moines to Memphis
The journey takes about 22 hours 35 minutes, and with fares starting at just $190, it presents an excellent value for a comfortable ride.
Where are the popular stops in Des Moines and Memphis?
Stops in Des Moines
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Frequently asked questions about travelling from Des Moines to Memphis, TN by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from Des Moines to Memphis?
The cheapest bus tickets from Des Moines to Memphis start from $190. The average price for this route is around $338. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Des Moines to Memphis?
The average bus travel time from Des Moines to Memphis is 22h 35m, covering a distance of 795 km. The quickest bus can get you there in 16h 25m and is operated by Jefferson Lines.
Which bus companies service the Des Moines to Memphis route?
Several major bus companies operate on this route with 2 buses available per day, including services from Jefferson Lines, Greyhound.
What are the earliest and latest departure times for the bus from Des Moines to Memphis?
The earliest bus departs from Des Moines to Memphis at 12:01am. And the latest bus departs at 9:45am.
What are the CO₂ emissions for the bus trip from Des Moines to Memphis?
A bus trip from Des Moines to Memphis generates an estimated 20 kg of CO₂, making it a highly eco-friendly travel option and a mode of travel recommended by Busbud.
What is the best bus company from Des Moines to Memphis?
According to Busbud customers, the highest-rated bus company on this route is Jefferson Lines, with an average rating of 3.9 out of 5 stars based on 764 reviews.
Which bus company has the best Wi-Fi from Des Moines to Memphis?
Based on Busbud reviews, the bus company Greyhound has the highest Wi-Fi rating with a score of 2.4.
Which bus company has the best on-time performance from Des Moines to Memphis?
According to Busbud traveller reviews, the most punctual bus company on this route is Jefferson Lines, with a punctuality rating of 3.5 out of 5 stars.
Which bus company has the cleanest buses from Des Moines to Memphis?
According to Busbud traveller reviews, the bus company with the cleanest buses on this route is Jefferson Lines, with a cleanliness rating of 4.3 out of 5 stars.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Des Moines to Memphis, TN was searched and found on Jan 12, 2026 with a price of $186To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Des Moines to Memphis, TN, as early as possible.
You can expect to pay from $186 to $258 for a bus ticket from Des Moines to Memphis, TN based on the last 2 days. You can expect to find the cheapest price for the trip at $186 which is on 2026-01-16.
Usually Greyhound will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.
