Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Bus station | Tampa Bus Station | CheapestFastest | ||||
Greyhound Lines, Inc. + FlixBus | Bus | Bus station | Tampa Bus Station | No tags | ||||
 | Bus | Bus station | Tampa Bus Station | No tags | ||||
| Bus | Florence, SC | Tampa Bus Station | No tags | ||||
Greyhound Lines, Inc. + FlixBus | Bus | Bus station | University of South Florida | No tags |
Last refresh of the prices: Today at 6:46 AM EST.
Compare 2 ways to go from Florence to Tampa
Among the sustainable travel choices, the train stands out as a good way to reach Tampa. The journey takes about 18 hours 30 minutes, and with fares starting at just $137, it presents an excellent value for a comfortable ride.
Compare bus companies
Where are the popular stops in Florence and Tampa?
Stops in Florence
- A619 S Irby St, Florence, SC 29501, USA
- B
TA Travel Center - Florence
2301 W Lucas St, Florence, SC 29501, USA
Stops in Tampa
- A
Tampa 13th Avenue Bus Stop (McDonald's)
2101 E 13th Ave (McDonald's), Tampa, FL 33605 - B
Tampa USF, FL
3801 USF Holly Drive, Tampa., FL 33620, USA - C
Greyhound Station
610 E Polk St, Tampa, FL 33602, USA - D
E Sligh Ave
11555 E Sligh Ave, Seffner, FL 33584, USA - E
N Marion St & E Laurel St
551 E Laurel St, Tampa, FL 33602, USA - F
Port of Tampa
200-298 FL-60, Tampa, FL 33602, USA
Frequently asked questions about travelling from Florence, SC, US to Tampa by bus
What is the distance between Florence and Tampa?
The distance between Florence and Tampa is approximately 747 km (464 miles).
What are the departure and arrival locations for buses traveling from Florence to Tampa?
Buses departing from Florence Bus Station in Florence will take you to Tampa 13th Avenue Bus Stop (McDonald's) in Tampa.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Florence, SC, US to Tampa was searched and found on Nov 20, 2025 with a price of $143To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Florence, SC, US to Tampa, as early as possible.
You can expect to pay from $143 to $251 for a bus ticket from Florence, SC, US to Tampa based on the last 2 days. You can expect to find the cheapest price for the trip at $151 which is on 2025-11-24.
Usually Greyhound will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.
What's the cheapest way to go from Florence, SC, US to Tampa?
The bus is the cheapest travel choice for this destination
