Next bus departures

Next departures for Florence to Wilmington on August 28
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
Greyhound Lines, Inc. + FlixBus	Bus	7:20pm	Bus station	18h 20m	1:40pm	Wilmington Bus Station	Cheapest
Greyhound Lines, Inc. + FlixBus	Bus	3:20pm	Bus station	14h 35m	5:55am	Wilmington Bus Station	Fastest
Greyhound Lines, Inc. + FlixBus	Bus	3:20pm	Bus station	16h	7:20am	Newark (DE)	No tags
Greyhound Lines, Inc. + FlixBus	Bus	7:20pm	Bus station	17h	12:20pm	Newark (DE)	No tags
Greyhound Lines, Inc. + FlixBus	Bus	7:20pm	Bus station	18h 40m	2:00pm	Delaware Rest Stop S	No tags

Next departures for Florence to Wilmington on August 29
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
Greyhound Lines, Inc. + FlixBus	Bus	3:20pm	Bus station	14h 35m	5:55am	Wilmington Bus Station	Cheapest
	Bus	12:05am	Florence, SC	12h 15m	12:20pm	Newark (DE)	Fastest
FlixBus + Greyhound Lines, Inc.	Bus	12:05am	Florence, SC	13h 35m	1:40pm	Wilmington Bus Station	No tags
	Bus	12:05am	Florence, SC	13h 55m	2:00pm	Delaware Rest Stop S	No tags
Greyhound Lines, Inc. + FlixBus	Bus	7:20pm	Bus station	18h 20m	1:40pm	Wilmington Bus Station	No tags
Greyhound Lines, Inc. + FlixBus	Bus	3:20pm	Bus station	16h	7:20am	Newark (DE)	No tags
Greyhound Lines, Inc. + FlixBus	Bus	7:20pm	Bus station	17h	12:20pm	Newark (DE)	No tags
Greyhound Lines, Inc. + FlixBus	Bus	7:20pm	Bus station	18h 40m	2:00pm	Delaware Rest Stop S	No tags

Next departures for Florence to Wilmington on August 30
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
Greyhound Lines, Inc. + FlixBus	Bus	7:20pm	Bus station	21h 10m	4:30pm	Newark (DE)	Cheapest
	Bus	12:05am	Florence, SC	12h 15m	12:20pm	Newark (DE)	Fastest
FlixBus + Greyhound Lines, Inc.	Bus	12:05am	Florence, SC	13h 35m	1:40pm	Wilmington Bus Station	No tags
	Bus	12:05am	Florence, SC	13h 55m	2:00pm	Delaware Rest Stop S	No tags
Greyhound Lines, Inc. + FlixBus	Bus	3:20pm	Bus station	14h 35m	5:55am	Wilmington Bus Station	No tags
Greyhound Lines, Inc. + FlixBus	Bus	7:20pm	Bus station	18h 20m	1:40pm	Wilmington Bus Station	No tags
Greyhound Lines, Inc. + FlixBus	Bus	3:20pm	Bus station	16h	7:20am	Newark (DE)	No tags
Greyhound Lines, Inc. + FlixBus	Bus	7:20pm	Bus station	18h 40m	2:00pm	Delaware Rest Stop S	No tags

Next departures for Florence to Wilmington on August 31
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
Greyhound Lines, Inc. + FlixBus	Bus	7:20pm	Bus station	21h 10m	4:30pm	Newark (DE)	Cheapest
FlixBus + Greyhound Lines, Inc.	Bus	12:05am	Florence, SC	13h 35m	1:40pm	Wilmington Bus Station	Fastest
FlixBus + Greyhound Lines, Inc.	Bus	5:45am	Florence, SC	1d	5:55am	Wilmington Bus Station	No tags
	Bus	12:05am	Florence, SC	13h 55m	2:00pm	Delaware Rest Stop S	No tags
Greyhound Lines, Inc. + FlixBus	Bus	3:20pm	Bus station	14h 35m	5:55am	Wilmington Bus Station	No tags
Greyhound Lines, Inc. + FlixBus	Bus	7:20pm	Bus station	21h 30m	4:50pm	Wilmington Bus Station	No tags
Greyhound Lines, Inc. + FlixBus	Bus	7:20pm	Bus station	22h 5m	5:25pm	Delaware Rest Stop S	No tags

Next departures for Florence to Wilmington on September 1
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
Greyhound Lines, Inc. + FlixBus	Bus	7:20pm	Bus station	21h 30m	4:50pm	Wilmington Bus Station	Cheapest
Greyhound Lines, Inc. + FlixBus	Bus	3:20pm	Bus station	14h 35m	5:55am	Wilmington Bus Station	Fastest
FlixBus + Greyhound Lines, Inc.	Bus	12:05am	Florence, SC	16h 45m	4:50pm	Wilmington Bus Station	No tags
	Bus	12:05am	Florence, SC	17h 20m	5:25pm	Delaware Rest Stop S	No tags
Greyhound Lines, Inc. + FlixBus	Bus	7:20pm	Bus station	21h 10m	4:30pm	Newark (DE)	No tags
Greyhound Lines, Inc. + FlixBus	Bus	7:20pm	Bus station	18h 40m	2:00pm	Delaware Rest Stop S	No tags

Last refresh of the prices: Yesterday at 7:40 PM EDT.

Compare 2 ways to go from Florence to Wilmington

We recommend taking the bus

Among the sustainable travel choices, the Bus stands out as a good way to reach Wilmington. The journey takes about 17 hours, and with fares starting at just PEN 216, it presents an excellent value for a comfortable ride.

7bus per day

17hAverage Duration

714 kmDistance

18kgCO₂ emissions

	Average Price	Average Duration	CO₂ emissions	Actions
Bus	Average PricePEN 216 - PEN 781	Average Duration17h	CO₂ emissions 18kg CO₂e
Train	Average PricePEN 332 - PEN 1,277	Average Duration10h 32m	CO₂ emissions 66kg CO₂e

Bus stations and stops in Florence and Wilmington

Stops in Florence

A
Florence Bus Station
619 S Irby St, Florence, SC 29501, USA
Visit page
B
TA Travel Center - Florence
2301 W Lucas St, Florence, SC 29501, USA

Stops in Wilmington

A
Wilmington Bus Station
Wilmington Bus Station, 101 N French St, Wilmington, DE 19801, USA
Visit page
B
Amtrak/SEPTA Station
100 French St, Wilmington, DE 19801, USA
Visit page
C
Wilmington Bus Stop
101 N French , Wilmington, DE 19801

Compare bus companies

FlixBus

3.5/515,395 reviews

Staff4.1

Timeliness4.0

Cleanliness4.1

Wi‑Fi2.7

Greyhound

3.5/588,093 reviews

Staff3.6

Timeliness3.0

Cleanliness3.4

Wi‑Fi2.5

US bus companies:FlixBus, Greyhound, Futura, Chihuahuenses, Tufesa, Adirondack Trailways, Elite

Frequently asked questions about travelling from Florence, SC, US to Wilmington, DE by bus

Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.

How much is the bus ticket from Florence to Wilmington?
The cheapest bus tickets from Florence to Wilmington start from PEN 216. The average price for this route is around PEN 343. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Florence to Wilmington?
The average bus travel time from Florence to Wilmington is 17h, covering a distance of 714 km. The quickest bus can get you there in 12h 15m and is operated by FlixBus.
Which bus companies service the Florence to Wilmington route?
Several major bus companies operate on this route with 7 buses available per day, including services from FlixBus, Greyhound.
What are the earliest and latest departure times for the bus from Florence to Wilmington?
The earliest bus departs from Florence to Wilmington at 12:05am. And the latest bus departs at 7:20pm.
What are the CO₂ emissions for the bus trip from Florence to Wilmington?
A bus trip from Florence to Wilmington generates an estimated 17.826974999999997 kg of CO₂, making it a highly eco-friendly travel option and a mode of travel recommended by Busbud.
What is the best bus company from Florence to Wilmington?
According to Busbud customers, the highest-rated bus company on this route is FlixBus, with an average rating of 3.5 out of 5 stars based on 15390 reviews.
Which bus company has the best Wi-Fi from Florence to Wilmington?
Based on Busbud reviews, the bus company FlixBus has the highest Wi-Fi rating with a score of 2.7.
Which bus company has the best on-time performance from Florence to Wilmington?
According to Busbud traveller reviews, the most punctual bus company on this route is FlixBus, with a punctuality rating of 4.0 out of 5 stars.
Which bus company has the cleanest buses from Florence to Wilmington?
According to Busbud traveller reviews, the bus company with the cleanest buses on this route is FlixBus, with a cleanliness rating of 4.1 out of 5 stars.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found

08-26

No data

08-27

PEN 351

Today

PEN 562

08-29

PEN 406

08-30

PEN 303

08-31

PEN 301

09-01

PEN 406

09-02

No data

The cheapest trip from Florence, SC, US to Wilmington, DE was searched and found on Aug 31, 2026 with a price of PEN 301

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Florence, SC, US to Wilmington, DE, as early as possible.

You can expect to pay from PEN 301 to PEN 565 for a bus ticket from Florence, SC, US to Wilmington, DE based on the last 2 days. You can expect to find the cheapest price for the trip at PEN 301 which is on 2026-08-31.