What is the travel distance from Florence to Orlando?

It's about 653 km (405 miles) from Florence to Orlando.

What are the departure and arrival locations for buses traveling from Florence to Orlando?

Buses traveling this route start their trip at Florence Bus Station, in Florence, and end it at Orlando Bus Station, in Orlando.

Bus Florence to Orlando from $82 | Refundable Tickets

Next bus departures

Next departures for Florence to Orlando on November 19
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
	Bus	4:00pm	Bus station	8h 55m	12:55am	Orlando Bus Station	CheapestFastest
	Bus	4:10pm	Bus station	16h 35m	8:45am	Orlando Bus Station	No tags
Greyhound Lines, Inc. + FlixBus	Bus	4:10pm	Bus station	19h	11:10am	Orlando Bus Station	No tags

Next departures for Florence to Orlando on November 20
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
	Bus	4:00pm	Bus station	8h 55m	12:55am	Orlando Bus Station	Cheapest
	Bus	5:45am	Florence, SC	8h 25m	2:10pm	Orlando Bus Station	Fastest
Greyhound Lines, Inc. + FlixBus	Bus	11:55am	Bus station	17h 55m	5:50am	Orlando Bus Station	No tags
	Bus	11:55am	Bus station	20h 50m	8:45am	Orlando Bus Station	No tags
Greyhound Lines, Inc. + FlixBus	Bus	11:55am	Bus station	23h 15m	11:10am	Orlando Bus Station	No tags

Next departures for Florence to Orlando on November 21
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
	Bus	4:00pm	Bus station	8h 55m	12:55am	Orlando Bus Station	Cheapest
	Bus	5:45am	Florence, SC	8h 25m	2:10pm	Orlando Bus Station	Fastest
Greyhound Lines, Inc. + FlixBus	Bus	11:55am	Bus station	17h 55m	5:50am	Orlando Bus Station	No tags
	Bus	11:55am	Bus station	20h 50m	8:45am	Orlando Bus Station	No tags
Greyhound Lines, Inc. + FlixBus	Bus	11:55am	Bus station	23h 15m	11:10am	Orlando Bus Station	No tags

Next departures for Florence to Orlando on November 22
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
	Bus	4:00pm	Bus station	8h 55m	12:55am	Orlando Bus Station	Cheapest
	Bus	5:45am	Florence, SC	8h 25m	2:10pm	Orlando Bus Station	Fastest
Greyhound Lines, Inc. + FlixBus	Bus	11:55am	Bus station	17h 55m	5:50am	Orlando Bus Station	No tags
	Bus	11:55am	Bus station	20h 50m	8:45am	Orlando Bus Station	No tags
Greyhound Lines, Inc. + FlixBus	Bus	11:55am	Bus station	23h 15m	11:10am	Orlando Bus Station	No tags

Next departures for Florence to Orlando on November 23
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
	Bus	4:00pm	Bus station	8h 55m	12:55am	Orlando Bus Station	Cheapest
	Bus	5:45am	Florence, SC	8h 25m	2:10pm	Orlando Bus Station	Fastest
Greyhound Lines, Inc. + FlixBus	Bus	11:55am	Bus station	17h 55m	5:50am	Orlando Bus Station	No tags
	Bus	11:55am	Bus station	20h 50m	8:45am	Orlando Bus Station	No tags
Greyhound Lines, Inc. + FlixBus	Bus	11:55am	Bus station	23h 15m	11:10am	Orlando Bus Station	No tags

Next departures for Florence to Orlando on November 24
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
	Bus	4:00pm	Bus station	8h 55m	12:55am	Orlando Bus Station	Cheapest
	Bus	5:45am	Florence, SC	8h 25m	2:10pm	Orlando Bus Station	Fastest
Greyhound Lines, Inc. + FlixBus	Bus	11:55am	Bus station	17h 55m	5:50am	Orlando Bus Station	No tags
	Bus	11:55am	Bus station	20h 50m	8:45am	Orlando Bus Station	No tags
Greyhound Lines, Inc. + FlixBus	Bus	11:55am	Bus station	23h 15m	11:10am	Orlando Bus Station	No tags

Last refresh of the prices: Yesterday at 6:30 PM EST.

Compare 2 ways to go from Florence to Orlando

We recommend taking the train

Among the sustainable travel choices, the train stands out as a good way to reach Orlando. The journey takes about 9 hours 46 minutes, and with fares starting at just $91, it presents an excellent value for a comfortable ride.

2train per day

9h 46mAverage Duration

650 kmDistance

59kgCO₂ emissions

	Average Price	Average Duration	CO₂ emissions	Actions
Bus	Average Price$83 - $281	Average Duration17h 55m	CO₂ emissions 16kg CO₂e
Train	Average Price$91 - $252	Average Duration9h 46m	CO₂ emissions 59kg CO₂e

Compare bus companies

Greyhound

3.5/587,382 reviews

Staff3.6

Timeliness2.9

Cleanliness3.3

Wifi2.4

FlixBus

3.5/511,376 reviews

Staff4.2

Timeliness3.9

Cleanliness4.1

Wifi2.7

US Bus Companies: FlixBus, BlaBlaCar Bus, ALSA, Greyhound, Intercape, Trenitalia, Sindbad

Where are the popular stops in Florence and Orlando?

Stops in Florence

A - Florence Bus Station

B - TA Travel Center - Florence

Stops in Orlando

A - Orlando Bus Station

B - Orlando RedCoach Station

C - Jet Set Express Terminal

D - Disney World

E - International Dr SuperTours Terminal

F - Seaworld Hotels

Frequently asked questions about travelling from Florence, SC, US to Orlando by bus

What is the travel distance from Florence to Orlando?
It's about 653 km (405 miles) from Florence to Orlando.
What are the departure and arrival locations for buses traveling from Florence to Orlando?
Buses traveling this route start their trip at Florence Bus Station, in Florence, and end it at Orlando Bus Station, in Orlando.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found

11-17

$101

11-18

$98

Today

$118

11-20

$107

11-21

$118

11-22

$118

11-23

$133

11-24

$121

The cheapest trip from Florence, SC, US to Orlando was searched and found on Nov 18, 2025 with a price of $98

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Florence, SC, US to Orlando, as early as possible.

You can expect to pay from $98 to $276 for a bus ticket from Florence, SC, US to Orlando based on the last 2 days. You can expect to find the cheapest price for the trip at $107 which is on 2025-11-20.

Usually Greyhound will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.