Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Rosa Parks Station | Port St. Lucie (Park & Ride) | Cheapest | ||||
| Bus | Rosa Parks Station | Port St. Lucie (Park & Ride) | Fastest | ||||
 | Bus | Gainesville Bus Stop | Port St. Lucie (Park & Ride) | No tags |
Last refresh of the prices: Last Tuesday at 6:19 PM EST.
Get from Gainesville to Port Saint Lucie
The journey takes about 9 hours 10 minutes, and with fares starting at just $116, it presents an excellent value for a comfortable ride.
Where are the popular stops in Gainesville and Port Saint Lucie?
Stops in Gainesville
- A700 SE 3rd St, Gainesville, FL 32601
- B3509 SW Williston Rd, Gainesville, FL 32608, USA
- C101 NE 23rd Ave, Gainesville, FL 32609
Stops in Port Saint Lucie
- A
Port St Lucie Mobil Gas Bus Stop
1820 Sw Fountainview Blvd, Port Saint Lucie, FL 34986 - B
Port Saint Lucie - Wendys
1790 SW St Lucie W Blvd, Port St Lucie, FL 34986 - C
Port Saint LucieService Plaza
Florida's Turnpike, Milepost 144, Port St Lucie, FL 34984, USA - D
Port Saint Lucie Bus Stop
2198 SW Gatlin Blvd. Port St. Lucie, FL 34953
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Frequently asked questions about travelling from Gainesville, FL to Port Saint Lucie by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from Gainesville to Port Saint Lucie?
The cheapest bus tickets from Gainesville to Port Saint Lucie start from $116. The average price for this route is around $146. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Gainesville to Port Saint Lucie?
The average bus travel time from Gainesville to Port Saint Lucie is 9h 10m, covering a distance of 324 km. The quickest bus can get you there in 5h 55m and is operated by FlixBus.
Which bus companies service the Gainesville to Port Saint Lucie route?
What are the earliest and latest departure times for the bus from Gainesville to Port Saint Lucie?
The earliest bus departs from Gainesville to Port Saint Lucie at 5:30am. And the latest bus departs at 9:20pm.
What are the CO₂ emissions for the bus trip from Gainesville to Port Saint Lucie?
A bus trip from Gainesville to Port Saint Lucie generates an estimated 8 kg of CO₂, making it a highly eco-friendly travel option and a mode of travel recommended by Busbud.
What is the best bus company from Gainesville to Port Saint Lucie?
According to Busbud customers, the highest-rated bus company on this route is FlixBus, with an average rating of 3.5 out of 5 stars based on 11380 reviews.
Which bus company has the best Wi-Fi from Gainesville to Port Saint Lucie?
Based on Busbud reviews, the bus company FlixBus has the highest Wi-Fi rating with a score of 2.7.
Which bus company has the best on-time performance from Gainesville to Port Saint Lucie?
According to Busbud traveller reviews, the most punctual bus company on this route is FlixBus, with a punctuality rating of 3.9 out of 5 stars.
Which bus company has the cleanest buses from Gainesville to Port Saint Lucie?
According to Busbud traveller reviews, the bus company with the cleanest buses on this route is FlixBus, with a cleanliness rating of 4.1 out of 5 stars.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Gainesville, FL to Port Saint Lucie was searched and found on Dec 2, 2025 with a price of $121To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Gainesville, FL to Port Saint Lucie, as early as possible.
You can expect to pay from $121 to $270 for a bus ticket from Gainesville, FL to Port Saint Lucie based on the last 2 days. You can expect to find the cheapest price for the trip at $121 which is on 2025-12-02.
Usually Greyhound will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.
