Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | 1116 Woodruff Rd | Jacksonville Bus Station | Cheapest | ||||
Greyhound Lines, Inc. + FlixBus | Bus | 1116 Woodruff Rd | Jacksonville Bus Station | Fastest | ||||
Greyhound Lines, Inc. + FlixBus | Bus | 1116 Woodruff Rd | Jacksonville Bus Station | No tags | ||||
| Bus | 1116 Woodruff Rd | Jacksonville Bus Station | No tags | ||||
FlixBus + Greyhound Lines, Inc. | Bus | 1116 Woodruff Rd | Jacksonville Bus Station | No tags |
Last refresh of the prices: Yesterday at 2:41 AM EST.
Compare 2 ways to go from Greenville to Jacksonville
Among the sustainable travel choices, the Bus stands out as a good way to reach Jacksonville. The journey takes about 11 hours, and with fares starting at just $111, it presents an excellent value for a comfortable ride.
Where are the popular stops in Greenville and Jacksonville?
Stops in Greenville
Stops in Jacksonville
- A3570 Clifford Ln, Jacksonville, FL 32209, USA
- B
W Forsyth St
1111 W Forsyth St, Jacksonville, FL 32204, USA - C
Kings Avenue Station
1003 Kings Avenue, Jacksonville, FL 32207 - D
JRTC Greyhound Bus Station
111 W. Forsyth St, Jacksonville, FL 32202, USA
Compare bus companies
Frequently asked questions about travelling from Greenville, SC to Jacksonville, FL by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from Greenville to Jacksonville?
The cheapest bus tickets from Greenville to Jacksonville start from $111. The average price for this route is around $188. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Greenville to Jacksonville?
The average bus travel time from Greenville to Jacksonville is 11h, covering a distance of 504 km. The quickest bus can get you there in 9h 45m and is operated by FlixBus.
Which bus companies service the Greenville to Jacksonville route?
What are the earliest and latest departure times for the bus from Greenville to Jacksonville?
The earliest bus departs from Greenville to Jacksonville at 7:25am. And the latest bus departs at 10:00pm.
What are the CO₂ emissions for the bus trip from Greenville to Jacksonville?
A bus trip from Greenville to Jacksonville generates an estimated 13 kg of CO₂, making it a highly eco-friendly travel option and a mode of travel recommended by Busbud.
What is the best bus company from Greenville to Jacksonville?
According to Busbud customers, the highest-rated bus company on this route is FlixBus, with an average rating of 3.5 out of 5 stars based on 11828 reviews.
Which bus company has the best Wi-Fi from Greenville to Jacksonville?
Based on Busbud reviews, the bus company FlixBus has the highest Wi-Fi rating with a score of 2.7.
Which bus company has the best on-time performance from Greenville to Jacksonville?
According to Busbud traveller reviews, the most punctual bus company on this route is FlixBus, with a punctuality rating of 3.9 out of 5 stars.
Which bus company has the cleanest buses from Greenville to Jacksonville?
According to Busbud traveller reviews, the bus company with the cleanest buses on this route is FlixBus, with a cleanliness rating of 4.1 out of 5 stars.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Greenville, SC to Jacksonville, FL was searched and found on Jan 10, 2026 with a price of $117To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Greenville, SC to Jacksonville, FL, as early as possible.
You can expect to pay from $117 to $186 for a bus ticket from Greenville, SC to Jacksonville, FL based on the last 2 days. You can expect to find the cheapest price for the trip at $117 which is on 2026-01-15.
What's the cheapest way to go from Greenville, SC to Jacksonville, FL?
The Bus is the cheapest travel choice for this destination
