What is the travel distance from Greenville to Jacksonville?

About 315 miles (508 km) separate Greenville and Jacksonville.

What are the departure and arrival stations when taking the bus from Greenville to Jacksonville?

The majority of buses traveling from Greenville to Jacksonville start their journey at Guadalajara Supermarket Bus Stop and wind up at Jacksonville Amtrak Station. These are the main departure and arrival locations on this route, but you can also find other options that could better fit your plans.

Bus Greenville to Jacksonville from $85 | Refundable Tickets

Previously seen trips

Next departures for Greenville to Jacksonville on November 15
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
FlixBus + Greyhound	Bus	1:25pm	1116 Woodruff Rd	18h 20m	7:45am	Jacksonville Bus Station	No tags
	Bus	4:35pm	1116 Woodruff Rd	18h 45m	11:20am	Jacksonville Bus Station	No tags
	Bus	10:50am	1116 Woodruff Rd	20h 25m	7:15am	Jacksonville Bus Station	No tags
FlixBus + Greyhound	Bus	3:30pm	1116 Woodruff Rd	23h 30m	3:00pm	Jacksonville Bus Station	No tags
FlixBus + Greyhound	Bus	8:20am	1116 Woodruff Rd	12h	8:20pm	Jacksonville Bus Station	No tags

Compare 2 ways to go from Greenville to Jacksonville

We recommend taking the bus

Among the sustainable travel choices, the bus stands out as the good way to reach Jacksonville. The journey takes about 11 hours 40 minutes and with fares starting at just $69, it presents an excellent value for a comfortable ride.

2bus per day

11h 40mAverage Duration

313 milesDistance

13kgCO₂ emissions

	Average Price	Average Duration	CO₂ emissions	Actions
Bus	Average Price$69 - $173	Average Duration11h 40m	CO₂ emissions 13kg CO₂e
Train	Average Price$158 - $2,099	Average Duration1d 4h	CO₂ emissions 46kg CO₂e

Compare bus companies

FlixBus

3.5/511,323 reviews

Staff4.1

Timeliness3.9

Cleanliness4.1

Wifi2.7

Flixbus is a European bus operator that offers intercity and bus travel in over 38 countries. Known for their easy-to-spot lime green buses and for offering affordable transportation between cities in Europe and the Americas, Flixbus is a good option for those looking for an affordable, reliable bus company. In their buses, you'll find free WiFi, bathrooms, and power outlets. You can also pay extra to choose your seat and get extra legroom, or even buy a snack or drink onboard directly from the driver. You can reschedule your ticket for a small fee, which varies from $1 to $5, depending on how close you are to the departure date.

Greyhound

3.5/587,373 reviews

Staff3.6

Timeliness2.9

Cleanliness3.3

Wifi2.4

Greyhound Lines offers the most comprehensive intercity bus services in the United States. They operate a modern, environmentally friendly fleet that serves more than 2400 destinations and carries nearly 16 million passengers annually. When traveling with them, you can expect free WiFi, onboard entertainment, bathrooms, power outlets and decent legroom. One of the great perks of Greyhound is that they connect big cities and smaller towns in the US, where you usually can't get to by train or plane. If you're looking for safe and affordable transportation, Greyhound is a great choice.

US bus companies: FlixBus, BlaBlaCar Bus, ALSA, Greyhound, Intercape, Trenitalia, Sindbad

Where are the popular stops in Greenville and Jacksonville?

Stops in Greenville

A - Guadalajara Supermarket Bus Stop

B - Greenville Bus Station

Stops in Jacksonville

A - Jacksonville Amtrak Station

B - W Forsyth St

C - Kings Avenue Station

D - JRTC Greyhound Bus Station

Frequently asked questions about traveling from Greenville, SC to Jacksonville, FL by bus

What is the travel distance from Greenville to Jacksonville?
What are the departure and arrival stations when taking the bus from Greenville to Jacksonville?

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found

11/13

No data

11/14

$118

Today

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11/16

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11/17

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11/18

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11/19

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11/20

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The cheapest trip from Greenville, SC to Jacksonville, FL was searched and found on Nov 14, 2025 with a price of $118

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Greenville, SC to Jacksonville, FL, as early as possible.