Bus Tickets from Greenville, SC to Lexington, KY

Next departures

Next departures for Greenville to Lexington on November 1
Operated byVehicle typeDeparture timeDeparture locationTrip durationArrival timeArrival locationRecommendedPrice and booking link
Greyhound Lines, Inc.
1116 Woodruff Rd
WJW Investments Bus StopCheapestFastest

Last refresh of the prices: Last Sunday at 5:50 PM EDT.

Accepted payments

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Get from Greenville to Lexington

busbud logoThis route is served by bus only

The journey takes about 11 hours, and with fares starting at just US$53, it presents an excellent value for a comfortable ride.

1bus per day
11hAverage Duration
410 kmDistance
10kgCO₂ emissions

Bus Greenville, SC to Lexington, KY: Trip Overview

Average Ticket PriceUS$128
Average Bus Trip Duration11h
Number of daily buses1
Earliest bus departure1:45pm
Distance410 km
Latest bus departure10:00pm

Greenville to Lexington Bus

Busbud helps you find a bus from Greenville to Lexington. Get the best fare and schedule, book a round trip ticket or find buses with WiFi and electrical outlets.

We make it our job to connect you with the most dependable bus companies that cover bus service from Greenville to Lexington.

From cheap bus tickets to more luxurious buses travelling from Greenville to Lexington, we offer a wide range of bus services to best suit your needs depending on how much your budget is.

Frequently asked questions on the trip Greenville, SC - Lexington, KY

  1. What is the distance between Greenville and Lexington?

    The distance covered from Greenville to Lexington is 399 km (248 miles).

  2. What are the departure and arrival locations for buses traveling from Greenville to Lexington?

    Buses traveling this route start their trip at Guadalajara Supermarket Bus Stop, in Greenville, and end it at WJW Investments Bus Stop, in Lexington.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
10-27
US$148
10-28
US$110
Today
US$110
10-30
No data
10-31
US$72
11-01
US$45
11-02
US$63
11-03
US$51
busbud logoThe cheapest trip from Greenville, SC to Lexington, KY was searched and found on Nov 1, 2025 with a price of US$45

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Greenville, SC to Lexington, KY, as early as possible.

You can expect to pay from US$45 to US$148 for a bus ticket from Greenville, SC to Lexington, KY based on the last 2 days. You can expect to find the cheapest price for the trip at US$45 which is on 2025-11-01.

About Bus Travel

Bus Travel Tips

Make friends with the driver. They usually know a lot about your destination and may even recommend which side of the bus to sit on to get the best views on the road between Greenville and Lexington!

From miles long of beauteous natural landscapes to impressive man-crafted sights, you’re bound to be in for a visual treat on your bus trip from Greenville to Lexington.

Taking the bus creates the smallest carbon footprint compared to other modes of transport. Not to mention that buses will allow you to discover scenic gems from Greenville to Lexington that are otherwise impossible to come by with a plane.

Tune out to the fine sounds of your best music playlist on your bus trip from Greenville to Lexington while indulging in miles on end of beautiful scenic views.

Did you know?

It takes 27 hours to go by bus from Lima to Cusco, one of the craziest bus trips on the world. This route is used daily by locals and backpackers.

Did you know some bus companies in Germany offer to their passenger low-costs snacks and regional beer based on their destination? Prosit!

One of the longest bus route in the world goes all the way from Ontario to Alberta in Canada (with the same bus). This trip is 3,435 km or 2,135 miles long and the price is a bit under $100.

Will you be returning to Greenville, SC by bus?

Bus from Lexington, KY to Greenville, SC

Why choose Busbud?

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