Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
FlixBus + Greyhound Lines, Inc. | Bus | Downtown Transit Center | 409 Townsend St, SF | Cheapest | ||||
 | Bus | Indianapolis Bus Station | San Francisco Bus Station | Fastest | ||||
Greyhound Lines, Inc. + FlixBus | Bus | Indianapolis Bus Station | 409 Townsend St, SF | No tags | ||||
| Bus | Indianapolis Bus Station | San Francisco Bus Station | No tags | ||||
Greyhound Lines, Inc. + FlixBus | Bus | Indianapolis Bus Station | 409 Townsend St, SF | No tags |
Last refresh of the prices: Yesterday at 5:59 AM EST.
Get from Indianapolis to San Francisco
The journey takes about 2 days, 15 hours 50 minutes, and with fares starting at just $191, it presents an excellent value for a comfortable ride.
Where are the popular stops in Indianapolis and San Francisco?
Stops in Indianapolis
- A350 S Illinois St, Indianapolis, IN 46225
Stops in San Francisco
- A
Hyde/Beach (Fisherman's Wharf)
700 Beach Street, San Francisco, CA 94109, USA - B
Powell Station
25 Cyril Magnin St , San Francisco, CA 94102-2812 - C
Union Square Hilton
255 Mason St,, San Francisco, CA 94102-2114 - D
San Francisco Greyhound Station
200 Folsom St, San Francisco, CA 94105 - E
444 Townsend St.
444 Townsend St, San Francisco, CA 94107, USA
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Frequently asked questions about travelling from Indianapolis to San Francisco, US by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from Indianapolis to San Francisco?
The cheapest bus tickets from Indianapolis to San Francisco start from $191. The average price for this route is around $535. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Indianapolis to San Francisco?
The average bus travel time from Indianapolis to San Francisco is 2d 15h, covering a distance of 3128 km. The quickest bus can get you there in 2d 5h and is operated by Greyhound.
Which bus companies service the Indianapolis to San Francisco route?
What are the earliest and latest departure times for the bus from Indianapolis to San Francisco?
The earliest bus departs from Indianapolis to San Francisco at 5:00am. And the latest bus departs at 11:30pm.
What are the CO₂ emissions for the bus trip from Indianapolis to San Francisco?
A bus trip from Indianapolis to San Francisco generates an estimated 78 kg of CO₂, making it a highly eco-friendly travel option and a mode of travel recommended by Busbud.
What is the best bus company from Indianapolis to San Francisco?
According to Busbud customers, the highest-rated bus company on this route is Amtrak, with an average rating of 4.1 out of 5 stars based on 5696 reviews.
Which bus company has the best Wi-Fi from Indianapolis to San Francisco?
Based on Busbud reviews, the bus company Amtrak has the highest Wi-Fi rating with a score of 3.6.
Which bus company has the best on-time performance from Indianapolis to San Francisco?
According to Busbud traveller reviews, the most punctual bus company on this route is FlixBus, with a punctuality rating of 3.9 out of 5 stars.
Which bus company has the cleanest buses from Indianapolis to San Francisco?
According to Busbud traveller reviews, the bus company with the cleanest buses on this route is Amtrak, with a cleanliness rating of 4.5 out of 5 stars.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Indianapolis to San Francisco, US was searched and found on Jan 19, 2026 with a price of $304To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Indianapolis to San Francisco, US, as early as possible.
You can expect to pay from $304 to $751 for a bus ticket from Indianapolis to San Francisco, US based on the last 2 days. You can expect to find the cheapest price for the trip at $304 which is on 2026-01-19.
