Bus Tickets from Jefferson City (MO) to Chicago

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SunJun 15
MonJun 16
from US$118
TueJun 17
from US$115
WedJun 18
from US$110
ThuJun 19
from US$90
FriJun 20
from US$98
SatJun 21
from US$160
SunJun 22

Cheap buses leaving Monday

One passenger / one way

  • This trip is recommended because it is the: Cheapest + Fastest
    Departure time: June 16 at
    Departure city: Jefferson City
    Departure location: Jefferson City
    Arrival time: June 17 at
    Destination city: Chicago
    Destination location: Chicago 95Th & Dan Ryan
    Operated by: Greyhound Lines, Inc.Greyhound Lines, Inc.
    Vehicle: BusDuration:
  • Departure time: June 16 at
    Departure city: Jefferson City
    Departure location: Jefferson City
    Arrival time: June 17 at
    Destination city: Chicago
    Destination location: Downtown Greyhound Station
    Operated by: Greyhound Lines, Inc.Greyhound Lines, Inc.
    Vehicle: BusDuration:
  • Departure time: June 16 at
    Departure city: Jefferson City
    Departure location: Jefferson City
    Arrival time: June 17 at
    Destination city: Chicago
    Destination location: 537-517 W. Jackson Blvd
    Operated by: Greyhound Lines, Inc.Greyhound Lines, Inc.
    Vehicle: BusDuration:

Last refresh of the prices: Today at 9:56 PM CDT.

Prices and availability are subject to change.

Accepted payments

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Compare 2 ways to go from Jefferson City to Chicago

Bus
Average PriceUS$63 - US$218Average Duration19h
13kg CO₂e5 out of 5 stars
Most eco-friendly
Train
Average PriceUS$49 - US$181Average Duration8h 11m
48kg CO₂e1 out of 5 stars
CheapestFastest
busbud logoBusbud recommends taking the train from Jefferson City to Chicago

Among the sustainable travel choices, the train stands out as a good way to reach Chicago. The journey takes about 8 hours 11 minutes, and with fares starting at just US$49, it presents an excellent value for a comfortable ride.

2train per day
8h 11mAverage Duration
US$49Cheapest ticket
48kgCO₂ emissions

Bus Jefferson City to Chicago: Trip Overview

Average Ticket PriceUS$103
Average Bus Trip Duration19h
Number of daily buses3
Earliest bus departure7:15pm
Distance532 km

Jefferson City to Chicago Bus

With Busbud, comparing and booking tickets for a bus from Jefferson City to Chicago is a breeze. Browse through an extensive selection of bus fares and bus schedules to find the best deals.

We make it our job to connect you with the most dependable bus companies that cover bus service from Jefferson City to Chicago.

Whether it is cheap bus tickets or more luxurious buses going to Chicago from Jefferson City, we help you find what you're looking for based on how much of a budget you have.

Frequently asked questions on the trip Jefferson City (MO) - Chicago

  1. How long is the trip from Jefferson City to Chicago by bus?

    The trip from Jefferson City to Chicago will take on average 19h. For the shortest travel time, select the fastest bus available, which will take you to Chicago in about 18h 45m.

  2. What is the travel distance from Jefferson City to Chicago?

    It's about 531 km (329 miles) from Jefferson City to Chicago.

  3. How much does the bus ticket cost from Jefferson City to Chicago?

    You can expect to pay around US$103 for the bus ride from Jefferson City to Chicago.

  4. Is there an overnight bus from Jefferson City to Chicago?

    Yes! If you're heading from Jefferson City to Chicago, you'll find buses departing until 7:15pm and arriving the next day.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
06-11
US$96
06-12
US$89
Today
US$114
06-14
US$88
06-15
US$130
06-16
US$110
06-17
US$107
06-18
US$102
busbud logoThe cheapest trip from Jefferson City to Chicago was searched and found on Jun 14, 2025 with a price of US$88

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Jefferson City to Chicago, as early as possible.

You can expect to pay from US$88 to US$162 for a bus ticket from Jefferson City to Chicago based on the last 2 days. You can expect to find the cheapest price for the trip at US$88 which is on 2025-06-14.

About Bus Travel

Bus Travel Tips

Meet and talk to locals at the bus stations while travelling from Jefferson City to Chicago.There is no better way to get inside travel information while exploring a new city than to go straight to its people.

From miles long of beauteous natural landscapes to impressive man-crafted sights, you’re bound to be in for a visual treat on your bus trip from Jefferson City to Chicago.

Buses are energy-efficient. Carrying a passenger over 100 kms by coach only takes 0.6-0.9 liters of gas. Compare that to the 2.6 liters required by high-speed train, 6.6 liters by airplane and 7.6 liters by gas-powered car, and it's clear that the bus is a more environmentally-conscious option for your bus transportation from Jefferson City to Chicago.

Make a music playlist for your bus ride from Jefferson City to Chicago, and enjoy the scenery to tunes from your own personal soundtrack.

Did you know?

One of the longest bus route in the world goes all the way from Ontario to Alberta in Canada (with the same bus). This trip is 3,435 km or 2,135 miles long and the price is a bit under $100.

Did you know some bus companies in Germany offer to their passenger low-costs snacks and regional beer based on their destination? Prosit!

The average number of passengers on a coach bus is 32 meaning that a bus could replace a minimum of at least 30 cars!

Will you be returning to Jefferson City by bus?

Bus from Jefferson City to Chicago

You can also go to Chicago by train

Train from Jefferson City to Chicago

Why choose Busbud?

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