What is the travel distance from Jefferson City to Chicago?

Jefferson City and Chicago are 329 miles (531 km) apart.

What are the best sights and things to do in Chicago?

Once in Chicago, you can start exploring the city and discover its surroundings. The top sights and things to do are Museum of Science and Industry, Shedd Aquarium, Willis Tower (Sears Tower), Auditorium Building and Theatre and Architectural River Cruise.

Bus Jefferson City to Chicago from $57 | Refundable Tickets

Next bus departures

Next departures for Jefferson City to Chicago on November 23
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
Greyhound Lines, Inc. + FlixBus	Bus	7:15pm	Jefferson City	10h 5m	5:20am	Chicago 95Th & Dan Ryan	CheapestFastest
Greyhound Lines, Inc. + FlixBus	Bus	7:15pm	Jefferson City	10h 30m	5:45am	Downtown Greyhound Station	No tags
	Bus	7:15pm	Jefferson City	18h 55m	2:10pm	537-517 W. Jackson Blvd	No tags

Next departures for Jefferson City to Chicago on November 24
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
Greyhound Lines, Inc. + FlixBus	Bus	7:15pm	Jefferson City	10h 30m	5:45am	Downtown Greyhound Station	Cheapest
Greyhound Lines, Inc. + FlixBus	Bus	7:15pm	Jefferson City	10h 5m	5:20am	Chicago 95Th & Dan Ryan	Fastest
	Bus	7:15pm	Jefferson City	18h 55m	2:10pm	537-517 W. Jackson Blvd	No tags

Next departures for Jefferson City to Chicago on November 25
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
Greyhound Lines, Inc. + FlixBus	Bus	7:15pm	Jefferson City	10h 5m	5:20am	Chicago 95Th & Dan Ryan	CheapestFastest
Greyhound Lines, Inc. + FlixBus	Bus	7:15pm	Jefferson City	10h 30m	5:45am	Downtown Greyhound Station	No tags
	Bus	7:15pm	Jefferson City	18h 55m	2:10pm	537-517 W. Jackson Blvd	No tags

Next departures for Jefferson City to Chicago on November 26
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
Greyhound Lines, Inc. + FlixBus	Bus	7:15pm	Jefferson City	10h 5m	5:20am	Chicago 95Th & Dan Ryan	CheapestFastest
Greyhound Lines, Inc. + FlixBus	Bus	7:15pm	Jefferson City	10h 30m	5:45am	Downtown Greyhound Station	No tags
	Bus	7:15pm	Jefferson City	18h 55m	2:10pm	537-517 W. Jackson Blvd	No tags

Next departures for Jefferson City to Chicago on November 27
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
Greyhound Lines, Inc. + FlixBus	Bus	7:15pm	Jefferson City	10h 5m	5:20am	Chicago 95Th & Dan Ryan	CheapestFastest
Greyhound Lines, Inc. + FlixBus	Bus	7:15pm	Jefferson City	10h 30m	5:45am	Downtown Greyhound Station	No tags
	Bus	7:15pm	Jefferson City	18h 55m	2:10pm	537-517 W. Jackson Blvd	No tags

Next departures for Jefferson City to Chicago on November 28
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
Greyhound Lines, Inc. + FlixBus	Bus	7:15pm	Jefferson City	10h 5m	5:20am	Chicago 95Th & Dan Ryan	CheapestFastest
Greyhound Lines, Inc. + FlixBus	Bus	7:15pm	Jefferson City	10h 30m	5:45am	Downtown Greyhound Station	No tags
	Bus	7:15pm	Jefferson City	18h 55m	2:10pm	537-517 W. Jackson Blvd	No tags

Next departures for Jefferson City to Chicago on November 29
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
Greyhound Lines, Inc. + FlixBus	Bus	7:15pm	Jefferson City	10h 5m	5:20am	Chicago 95Th & Dan Ryan	CheapestFastest
Greyhound Lines, Inc. + FlixBus	Bus	7:15pm	Jefferson City	10h 30m	5:45am	Downtown Greyhound Station	No tags
	Bus	7:15pm	Jefferson City	18h 55m	2:10pm	537-517 W. Jackson Blvd	No tags

Next departures for Jefferson City to Chicago on November 30
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
Greyhound Lines, Inc. + FlixBus	Bus	7:15pm	Jefferson City	10h 5m	5:20am	Chicago 95Th & Dan Ryan	CheapestFastest
Greyhound Lines, Inc. + FlixBus	Bus	7:15pm	Jefferson City	10h 30m	5:45am	Downtown Greyhound Station	No tags
	Bus	7:15pm	Jefferson City	18h 55m	2:10pm	537-517 W. Jackson Blvd	No tags

Last refresh of the prices: Yesterday at 10:10 PM CST.

Compare 2 ways to go from Jefferson City to Chicago

We recommend taking the train

Among the sustainable travel choices, the train stands out as the good way to reach Chicago. The journey takes about 8 hours 11 minutes and with fares starting at just $49, it presents an excellent value for a comfortable ride.

2train per day

8h 11mAverage Duration

330 milesDistance

48kgCO₂ emissions

	Average Price	Average Duration	CO₂ emissions	Actions
Bus	Average Price$56 - $174	Average Duration10h 30m	CO₂ emissions 13kg CO₂e
Train	Average Price$49 - $147	Average Duration8h 11m	CO₂ emissions 48kg CO₂e

Compare bus companies

Greyhound

3.5/587,391 reviews

Staff3.6

Timeliness2.9

Cleanliness3.3

Wifi2.4

Greyhound Lines offers the most comprehensive intercity bus services in the United States. They operate a modern, environmentally friendly fleet that serves more than 2400 destinations and carries nearly 16 million passengers annually. When traveling with them, you can expect free WiFi, onboard entertainment, bathrooms, power outlets and decent legroom. One of the great perks of Greyhound is that they connect big cities and smaller towns in the US, where you usually can't get to by train or plane. If you're looking for safe and affordable transportation, Greyhound is a great choice.

US bus companies: FlixBus, BlaBlaCar Bus, ALSA, Greyhound, Intercape, Trenitalia, Sindbad

Frequently asked questions about traveling from Jefferson City, MO to Chicago by bus

What is the travel distance from Jefferson City to Chicago?
What are the best sights and things to do in Chicago?

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found

11/21

$149

11/22

$127

Today

$133

11/24

$194

11/25

$189

11/26

$131

11/27

$118

11/28

$176

The cheapest trip from Jefferson City, MO to Chicago was searched and found on Nov 27, 2025 with a price of $118

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Jefferson City, MO to Chicago, as early as possible.

You can expect to pay from $118 to $194 for a bus ticket from Jefferson City, MO to Chicago based on the last 2 days. You can expect to find the cheapest price for the trip at $118 which is on 2025-11-27.