Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Key Largo | Tupelo (Brothers Quick Stop) | CheapestFastest |
Last refresh of the prices: Last Friday at 2:57 PM EST.
Get from Key Largo to Tupelo
The journey takes about 1 day, 2 hours 45 minutes, and with fares starting at just $173, it presents an excellent value for a comfortable ride.
Compare bus companies
Based on 87434 reviews, the company was rated 3.5 stars on Busbud. Travellers were especially satisfied with the ticket access and the temperature but often complained with the WiFi. Greyhound ticket prices on this trip start at $173
Frequently asked questions about travelling from Key Largo to Tupelo by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from Key Largo to Tupelo?
The cheapest bus tickets from Key Largo to Tupelo start from $173. The average price for this route is around $194. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Key Largo to Tupelo?
The average bus travel time from Key Largo to Tupelo is 1d 2h, covering a distance of 1291 km. The quickest bus can get you there in 1d 2h and is operated by Greyhound.
Which bus companies service the Key Largo to Tupelo route?
Several major bus companies operate on this route with 1 buses available per day.
What are the earliest and latest departure times for the bus from Key Largo to Tupelo?
The earliest bus departs from Key Largo to Tupelo at 7:40pm. And the latest bus departs at 7:40pm.
What are the CO₂ emissions for the bus trip from Key Largo to Tupelo?
A bus trip from Key Largo to Tupelo generates an estimated 32 kg of CO₂, making it a highly eco-friendly travel option and a mode of travel recommended by Busbud.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Key Largo to Tupelo was searched and found on Dec 15, 2025 with a price of $167To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Key Largo to Tupelo, as early as possible.
You can expect to pay from $167 to $206 for a bus ticket from Key Largo to Tupelo based on the last 2 days. You can expect to find the cheapest price for the trip at $167 which is on 2025-12-18.
