Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Key Largo | Tupelo (Brothers Quick Stop) | CheapestFastest |
Last refresh of the prices: Last Wednesday at 4:36 AM EST.
Get from Key Largo to Tupelo
The journey takes about 1 day, 2 hours 45 minutes and with fares starting at just $123, it presents an excellent value for a comfortable ride.
Compare bus companies
Greyhound Lines offers the most comprehensive intercity bus services in the United States. They operate a modern, environmentally friendly fleet that serves more than 2400 destinations and carries nearly 16 million passengers annually. When traveling with them, you can expect free WiFi, onboard entertainment, bathrooms, power outlets and decent legroom. One of the great perks of Greyhound is that they connect big cities and smaller towns in the US, where you usually can't get to by train or plane. If you're looking for safe and affordable transportation, Greyhound is a great choice.
Frequently asked questions about traveling from Key Largo to Tupelo by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from Key Largo to Tupelo?
The cheapest bus tickets from Key Largo to Tupelo start from $123. The average price for this route is around $138. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Key Largo to Tupelo?
The average bus trip duration from Key Largo to Tupelo is 1d 2h, covering a distance of 801 miles (1291 km). The quickest bus can get you there in 1d 2h and is operated by Greyhound.
Which bus companies service the Key Largo to Tupelo route?
Several major train operators operate on this route with 1 trains available per day.
What is the earliest and latest departure time for the bus from Key Largo to Tupelo?
The earliest bus departs from Key Largo to Tupelo at 7:40pm. And the latest bus departs at 7:40pm.
What are the CO₂ emissions for the bus trip from Key Largo to Tupelo?
A bus trip from Key Largo to Tupelo generates an estimated 32 kg of CO₂, making it a highly eco-friendly travel option and recommended mode of travel by Busbud.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Key Largo to Tupelo was searched and found on Dec 15, 2025 with a price of $118To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Key Largo to Tupelo, as early as possible.
You can expect to pay from $118 to $146 for a bus ticket from Key Largo to Tupelo based on the last 2 days. You can expect to find the cheapest price for the trip at $118 which is on 2025-12-18.
