Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Knoxville Bus Station | Harrisburg Bus Station | CheapestFastest |
Last refresh of the prices: Last Monday at 1:06 PM EST.
Get from Knoxville to Harrisburg
The journey takes about 15 hours 5 minutes, and with fares starting at just $137, it presents an excellent value for a comfortable ride.
Where are the popular stops in Knoxville and Harrisburg?
Stops in Knoxville
- AKnoxville Area Transit Bus Stop, 100 Kirkwood St, Knoxville, TN 37914, USA
Stops in Harrisburg
- A
Harrisburg Bieber Greyhound Station
411 Market St, Harrisburg, PA 17101
Compare bus companies
Based on 87518 reviews, the company was rated 3.5 stars on Busbud. Travellers were especially satisfied with the ticket access and the temperature but often complained with the Wi‑Fi. Greyhound ticket prices on this trip start at $137
Frequently asked questions about travelling from Knoxville, TN to Harrisburg by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from Knoxville to Harrisburg?
The cheapest bus tickets from Knoxville to Harrisburg start from $137. The average price for this route is around $215. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Knoxville to Harrisburg?
The average bus travel time from Knoxville to Harrisburg is 15h 5m, covering a distance of 774 km. The quickest bus can get you there in 15h 5m and is operated by Greyhound.
Which bus companies service the Knoxville to Harrisburg route?
Several major bus companies operate on this route with 1 buses available per day.
What are the earliest and latest departure times for the bus from Knoxville to Harrisburg?
The earliest bus departs from Knoxville to Harrisburg at 7:40pm. And the latest bus departs at 10:50pm.
What are the CO₂ emissions for the bus trip from Knoxville to Harrisburg?
A bus trip from Knoxville to Harrisburg generates an estimated 19 kg of CO₂, making it a highly eco-friendly travel option and a mode of travel recommended by Busbud.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Knoxville, TN to Harrisburg was searched and found on Jan 29, 2026 with a price of $127To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Knoxville, TN to Harrisburg, as early as possible.
You can expect to pay from $127 to $234 for a bus ticket from Knoxville, TN to Harrisburg based on the last 2 days. You can expect to find the cheapest price for the trip at $127 which is on 2026-01-29.
